Akash Roy1, Banashree Mondal2, Rebecca Banerjee2, Supriyo Choudhury2, Koustav Chatterjee2, Sanjit Dey3, Hrishikesh Kumar4. 1. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India. 2. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. 3. Department of Physiology, University of Calcutta, Kolkata, India; UGC Centre for Nanoscience and Nanotechnology and UGC Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, Kolkata, India. Electronic address: sdeyphys@caluniv.ac.in. 4. Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. Electronic address: rishi_medicine@yahoo.com.
Abstract
BACKGROUND: Inflammation along with oxidative stress alters neuroplasticity which might contribute to neurodegeneration in Parkinson's disease (PD). OBJECTIVES: We aimed to explore the correlation of inflammatory-oxidative and neurotrophic changes in PD and their association with clinical staging and motor severity. METHODS: Serum oxidative markers, pro and anti-inflammatory cytokines and BDNF levels were estimated by spectrophotometric and ELISA techniques. RESULTS: Redox-Inflammatory and neurotrophic markers significantly altered in PD and strongly correlated with motor severity and stagings of PD. CONCLUSION: This study establishes a link between peripheral immune-neurotrophic markers and disease severity in PD. This can lead to novel future therapeutics.
BACKGROUND:Inflammation along with oxidative stress alters neuroplasticity which might contribute to neurodegeneration in Parkinson's disease (PD). OBJECTIVES: We aimed to explore the correlation of inflammatory-oxidative and neurotrophic changes in PD and their association with clinical staging and motor severity. METHODS: Serum oxidative markers, pro and anti-inflammatory cytokines and BDNF levels were estimated by spectrophotometric and ELISA techniques. RESULTS: Redox-Inflammatory and neurotrophic markers significantly altered in PD and strongly correlated with motor severity and stagings of PD. CONCLUSION: This study establishes a link between peripheral immune-neurotrophic markers and disease severity in PD. This can lead to novel future therapeutics.