Literature DB >> 33756119

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family.

Yoko Katsuno1, Rik Derynck2.   

Abstract

Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics to migrate to other locations and acquire new properties. Epithelial plasticity responses are directed through cooperation of signaling pathways, with TGF-β and TGF-β-related proteins playing prominent instructive roles. Epithelial-mesenchymal transitions (EMTs) directed by activin-like molecules, bone morphogenetic proteins, or TGF-β regulate metazoan development and wound healing and drive fibrosis and cancer progression. In carcinomas, diverse EMTs enable stem cell generation, anti-cancer drug resistance, genomic instability, and localized immunosuppression. This review discusses roles of TGF-β and TGF-β-related proteins, and underlying molecular mechanisms, in epithelial plasticity in development and wound healing, fibrosis, and cancer.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  activins; bone morphogenetic proteins; cancer; cell invasion; cell migration; fibrosis; stem cell properties; wound healing

Year:  2021        PMID： 33756119     DOI： 10.1016/j.devcel.2021.02.028

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  21 in total

Review 1.  Overcoming TGFβ-mediated immune evasion in cancer.

Authors:  Daniele V F Tauriello; Elena Sancho; Eduard Batlle
Journal:  Nat Rev Cancer       Date:  2021-10-20       Impact factor: 60.716

2.  [Vasohibin-2 promotes proliferation and metastasis of cervical cancer cells by regulating epithelial-mesenchymal transition].

Authors:  J Wang; C Yu; X Jiang; X Wu; Y Jia; H Zhang; Z Li
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2022-07-20

Review 3.  Combination Therapy of Stem Cell-derived Exosomes and Biomaterials in the Wound Healing.

Authors:  Ali Golchin; Forough Shams; Arefeh Basiri; Parviz Ranjbarvan; Samaneh Kiani; Roya Sarkhosh-Inanlou; Abdolreza Ardeshirylajimi; Shiva Gholizadeh-Ghaleh Aziz; Sanaz Sadigh; Yousef Rasmi
Journal:  Stem Cell Rev Rep       Date:  2022-01-26       Impact factor: 6.692

Review 4.  Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1/TGFβRII agent: Current status.

Authors:  Sofia R Gameiro; Julius Strauss; James L Gulley; Jeffrey Schlom
Journal:  Exp Biol Med (Maywood)       Date:  2022-04-27

5.  Mitosis, a springboard for epithelial-mesenchymal transition?

Authors:  Evangéline Despin-Guitard; Isabelle Migeotte
Journal:  Cell Cycle       Date:  2021-10-31       Impact factor: 4.534

6.  Human embryonic mesenchymal lung-conditioned medium promotes differentiation to myofibroblast and loss of stemness phenotype in lung adenocarcinoma cell lines.

Authors:  Jordi Canals; Alfons Navarro; Cristina Vila; Josep M Canals; Tania Díaz; Melissa Acosta-Plasencia; Coralí Cros-Font; Bing Han; Yangyi He; Mariano Monzó
Journal:  J Exp Clin Cancer Res       Date:  2022-01-26

Review 7.  The emerging roles of exosomal long non-coding RNAs in bladder cancer.

Authors:  Qiang Liu
Journal:  J Cell Mol Med       Date:  2022-01-03       Impact factor: 5.310

Review 8.  Understanding the Renal Fibrotic Process in Leptospirosis.

Authors:  Luan Gavião Prado; Angela Silva Barbosa
Journal:  Int J Mol Sci       Date:  2021-10-05       Impact factor: 6.208

Review 9.  Mechanisms of Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas.

Authors:  Ana Belén Griso; Lucía Acero-Riaguas; Beatriz Castelo; José Luis Cebrián-Carretero; Ana Sastre-Perona
Journal:  Cells       Date:  2022-02-05       Impact factor: 6.600

Review 10.  Cell Fusion-Related Proteins and Signaling Pathways, and Their Roles in the Development and Progression of Cancer.

Authors:  Hao Zhang; Hong Ma; Xiaohui Yang; Linlin Fan; Shifeng Tian; Rui Niu; Man Yan; Minying Zheng; Shiwu Zhang
Journal:  Front Cell Dev Biol       Date:  2022-02-01
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