Mette Sørensen1,2, Aslak Harbo Poulsen1, Ulla Arthur Hvidtfeldt1, Thomas Münzel3, Jesse Daniel Thacher1, Matthias Ketzel4,5, Jørgen Brandt4,6, Jesper H Christensen4, Gregor Levin4, Ole Raaschou-Nielsen1,4. 1. Diet, Genes and Environment, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, Denmark. 2. Department of Natural Science and Environment, Roskilde University, Universitetsvej 1, Roskilde, Denmark. 3. University Medical Center Mainz of the Johannes Gutenberg University, Center for Cardiology, Cardiology I, Langenbeckstrasse 1, Mainz, Germany. 4. Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde, Denmark. 5. Global Centre for Clean Air Research, University of Surrey, Guildford, Surrey, UK. 6. iClimate-Aarhus University Interdisciplinary Centre for Climate Change, Frederiksborgvej 399, Roskilde, Denmark.
Abstract
BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population. METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the period 1990-2017. Based on this, we estimated the 10-year time-weighted mean noise exposure for 3.6 million Danes aged >35 years, of whom 184 523 developed incident stroke during follow-up from 2000 to 2017. Analyses were conducted using Cox proportional-hazards models, with adjustment for various individual- and area-level demographic and socio-economic covariates collected from registries and air pollution [fine particulate matter with particles with a diameter of ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2)]. RESULTS: A 10-dB increase in the 10-year mean road-traffic noise at the most exposed façade was associated with an incidence rate ratio (IRR) of 1.04 [95% confidence interval (CI): 1.03-1.05] for all strokes. For road-traffic noise at the least exposed façade, the IRR per 10 dB was 1.03 (95% CI: 1.02-1.04) for all strokes. Railway noise was not associated with a higher risk of stroke. CONCLUSION: Road-traffic noise increased the risk of stroke. These findings add to the evidence of road-traffic noise as a cardiovascular risk factor.
BACKGROUND: Studies on transportation noise and incident stroke are few and inconclusive. We aimed to investigate associations between road-traffic and railway noise and the risk of incident stroke in the entire Danish population. METHODS: We estimated road-traffic and railway noise (Lden) at the most and least exposed façades for all residential addresses across Denmark (2.8 million) for the period 1990-2017. Based on this, we estimated the 10-year time-weighted mean noise exposure for 3.6 million Danes aged >35 years, of whom 184 523 developed incident stroke during follow-up from 2000 to 2017. Analyses were conducted using Cox proportional-hazards models, with adjustment for various individual- and area-level demographic and socio-economic covariates collected from registries and air pollution [fine particulate matter with particles with a diameter of ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2)]. RESULTS: A 10-dB increase in the 10-year mean road-traffic noise at the most exposed façade was associated with an incidence rate ratio (IRR) of 1.04 [95% confidence interval (CI): 1.03-1.05] for all strokes. For road-traffic noise at the least exposed façade, the IRR per 10 dB was 1.03 (95% CI: 1.02-1.04) for all strokes. Railway noise was not associated with a higher risk of stroke. CONCLUSION: Road-traffic noise increased the risk of stroke. These findings add to the evidence of road-traffic noise as a cardiovascular risk factor.
Authors: Jesse D Thacher; Aslak H Poulsen; Ulla A Hvidtfeldt; Ole Raaschou-Nielsen; Jørgen Brandt; Camilla Geels; Jibran Khan; Thomas Münzel; Mette Sørensen Journal: Environ Health Perspect Date: 2021-12-02 Impact factor: 9.031
Authors: Jesse D Thacher; Nina Roswall; Claudia Lissåker; Gunn Marit Aasvang; Maria Albin; Eva M Andersson; Gunnar Engström; Charlotta Eriksson; Ulla Arthur Hvidtfeldt; Matthias Ketzel; Jibran Khan; Timo Lanki; Petter L S Ljungman; Kristoffer Mattisson; Peter Molnar; Ole Raaschou-Nielsen; Anna Oudin; Kim Overvad; Sesilje Bondo Petersen; Göran Pershagen; Aslak Harbo Poulsen; Andrei Pyko; Debora Rizzuto; Annika Rosengren; Linus Schioler; Mattias Sjöström; Leo Stockfelt; Pekka Tiittanen; Gerd Sallsten; Mikael Ögren; Jenny Selander; Mette Sorensen Journal: Occup Environ Med Date: 2022-04-21 Impact factor: 4.948
Authors: Elisa Bustaffa; Olivia Curzio; Gabriele Donzelli; Francesca Gorini; Nunzia Linzalone; Marco Redini; Fabrizio Bianchi; Fabrizio Minichilli Journal: Int J Environ Res Public Health Date: 2022-08-14 Impact factor: 4.614