Junxiang Liu1, Yangzhen Shao2, Jing Bai3, Yafei Shen3, Yifei Chen1,4, Dongliang Liu5, Haoran Wang6. 1. Department of Ultrasound, Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, Luohe, China. 2. Department of Endocrinology and Diabetes, Sahlgrenska University Hospital, Gothenburg, Sweden. 3. Department of Endocrinology and Diabetes, Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, Luohe, China. 4. Henan University of Science and Technology, Luoyang, China. 5. Department of Cardiology, Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, 56# Renmin Ave., Luohe, 462000, China. dongliang003@live.cn. 6. Department of Cardiology, Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, 56# Renmin Ave., Luohe, 462000, China. washingtonhr@163.com.
Abstract
PURPOSE: Snoring is one of the cardinal presentations of obstructive sleep apnea (OSA) and is more common than OSA. Abundant evidence has suggested a robust association between OSA and coronary artery disease (CAD). However, whether or not snoring alone is related to a higher risk of CAD is unknown. This study systematically reviewed observational studies with meta-analysis to evaluate the linkage between snoring and CAD. METHODS AND RESULTS: We searched PubMed and Embase and retrieved 13 articles focusing on the relationship between snoring and CAD. These articles included a total of 151,366 participants and 9099 CAD patients. Quantitative analysis indicated that snoring was associated with a 28% (RR: 1.28, 95% CI: 1.13 to 1.45, P < 0.001) increase in the risk of developing CAD. CONCLUSIONS: Snorers are exposed to a 28% increased risk for CAD. Although the association may be partly mediated through OSA, most snorers are not affected by apnea. Given the high prevalence of snoring and the disease burden of CAD in the general population, screening for snoring may be worthwhile for the early prevention of CAD.
PURPOSE: Snoring is one of the cardinal presentations of obstructive sleep apnea (OSA) and is more common than OSA. Abundant evidence has suggested a robust association between OSA and coronary artery disease (CAD). However, whether or not snoring alone is related to a higher risk of CAD is unknown. This study systematically reviewed observational studies with meta-analysis to evaluate the linkage between snoring and CAD. METHODS AND RESULTS: We searched PubMed and Embase and retrieved 13 articles focusing on the relationship between snoring and CAD. These articles included a total of 151,366 participants and 9099 CAD patients. Quantitative analysis indicated that snoring was associated with a 28% (RR: 1.28, 95% CI: 1.13 to 1.45, P < 0.001) increase in the risk of developing CAD. CONCLUSIONS: Snorers are exposed to a 28% increased risk for CAD. Although the association may be partly mediated through OSA, most snorers are not affected by apnea. Given the high prevalence of snoring and the disease burden of CAD in the general population, screening for snoring may be worthwhile for the early prevention of CAD.
Authors: Gordon Guyatt; Andrew D Oxman; Elie A Akl; Regina Kunz; Gunn Vist; Jan Brozek; Susan Norris; Yngve Falck-Ytter; Paul Glasziou; Hans DeBeer; Roman Jaeschke; David Rind; Joerg Meerpohl; Philipp Dahm; Holger J Schünemann Journal: J Clin Epidemiol Date: 2010-12-31 Impact factor: 6.437