| Literature DB >> 33753484 |
Dillan J Newbold1, Evan M Gordon2, Timothy O Laumann3, Nicole A Seider4, David F Montez4,3, Sarah J Gross4, Annie Zheng4, Ashley N Nielsen4,5, Catherine R Hoyt6, Jacqueline M Hampton3, Mario Ortega4, Babatunde Adeyemo4, Derek B Miller4, Andrew N Van4,7, Scott Marek4, Bradley L Schlaggar8,9,10, Alexandre R Carter4,6, Benjamin P Kay4, Deanna J Greene2,3, Marcus E Raichle4,2, Steven E Petersen4,2,7,11,12, Abraham Z Snyder4,2, Nico U F Dosenbach1,2,6,7,13.
Abstract
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.Entities:
Keywords: disuse; fMRI; network neuroscience; plasticity; spontaneous activity
Year: 2021 PMID： 33753484 PMCID： PMC8020791 DOI： 10.1073/pnas.2019128118
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205