Mingli Wang1,2,3, Huikuan Gu1,2,3, Jiang Hu1,2,3, Jian Liang1,2,3, Sisi Xu1,2,3, Zhenyu Qi4,5,6. 1. Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China. 2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. 3. Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. 4. Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China. qizhy@sysucc.org.cn. 5. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. qizhy@sysucc.org.cn. 6. Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. qizhy@sysucc.org.cn.
Abstract
BACKGROUND AND PURPOSE: To explore whether a highly refined dose volume histograms (DVH) prediction model can improve the accuracy and reliability of knowledge-based volumetric modulated arc therapy (VMAT) planning for cervical cancer. METHODS AND MATERIALS: The proposed model underwent repeated refining through progressive training until the training samples increased from initial 25 prior plans up to 100 cases. The estimated DVHs derived from the prediction models of different runs of training were compared in 35 new cervical cancer patients to analyze the effect of such an interactive plan and model evolution method. The reliability and efficiency of knowledge-based planning (KBP) using this highly refined model in improving the consistency and quality of the VMAT plans were also evaluated. RESULTS: The prediction ability was reinforced with the increased number of refinements in terms of normal tissue sparing. With enhanced prediction accuracy, more than 60% of automatic plan-6 (AP-6) plans (22/35) can be directly approved for clinical treatment without any manual revision. The plan quality scores for clinically approved plans (CPs) and manual plans (MPs) were on average 89.02 ± 4.83 and 86.48 ± 3.92 (p < 0.001). Knowledge-based planning significantly reduced the Dmean and V18 Gy for kidney (L/R), the Dmean, V30 Gy, and V40 Gy for bladder, rectum, and femoral head (L/R). CONCLUSION: The proposed model evolution method provides a practical way for the KBP to enhance its prediction ability with minimal human intervene. This highly refined prediction model can better guide KBP in improving the consistency and quality of the VMAT plans.
BACKGROUND AND PURPOSE: To explore whether a highly refined dose volume histograms (DVH) prediction model can improve the accuracy and reliability of knowledge-based volumetric modulated arc therapy (VMAT) planning for cervical cancer. METHODS AND MATERIALS: The proposed model underwent repeated refining through progressive training until the training samples increased from initial 25 prior plans up to 100 cases. The estimated DVHs derived from the prediction models of different runs of training were compared in 35 new cervical cancerpatients to analyze the effect of such an interactive plan and model evolution method. The reliability and efficiency of knowledge-based planning (KBP) using this highly refined model in improving the consistency and quality of the VMAT plans were also evaluated. RESULTS: The prediction ability was reinforced with the increased number of refinements in terms of normal tissue sparing. With enhanced prediction accuracy, more than 60% of automatic plan-6 (AP-6) plans (22/35) can be directly approved for clinical treatment without any manual revision. The plan quality scores for clinically approved plans (CPs) and manual plans (MPs) were on average 89.02 ± 4.83 and 86.48 ± 3.92 (p < 0.001). Knowledge-based planning significantly reduced the Dmean and V18 Gy for kidney (L/R), the Dmean, V30 Gy, and V40 Gy for bladder, rectum, and femoral head (L/R). CONCLUSION: The proposed model evolution method provides a practical way for the KBP to enhance its prediction ability with minimal human intervene. This highly refined prediction model can better guide KBP in improving the consistency and quality of the VMAT plans.
Authors: Enzhuo M Quan; Xiaoqiang Li; Yupeng Li; Xiaochun Wang; Rajat J Kudchadker; Jennifer L Johnson; Deborah A Kuban; Andrew K Lee; Xiaodong Zhang Journal: Int J Radiat Oncol Biol Phys Date: 2012-07-15 Impact factor: 7.038
Authors: Steven F Petit; Binbin Wu; Michael Kazhdan; André Dekker; Patricio Simari; Rachit Kumar; Russel Taylor; Joseph M Herman; Todd McNutt Journal: Radiother Oncol Date: 2011-06-15 Impact factor: 6.280
Authors: Binbin Wu; Francesco Ricchetti; Giuseppe Sanguineti; Michael Kazhdan; Patricio Simari; Robert Jacques; Russell Taylor; Todd McNutt Journal: Int J Radiat Oncol Biol Phys Date: 2010-08-26 Impact factor: 7.038
Authors: Binbin Wu; Francesco Ricchetti; Giuseppe Sanguineti; Misha Kazhdan; Patricio Simari; Ming Chuang; Russell Taylor; Robert Jacques; Todd McNutt Journal: Med Phys Date: 2009-12 Impact factor: 4.071