| Literature DB >> 3375136 |
G Gauquelin1, C Gharib, F Ghaemmaghami, A M Allevard, F Cherbal, G Geelen, F Bouzeghrane, J J Legros.
Abstract
Arginine vasopressin (AVP), oxytocin (OT) and neurophysins (Np) have been found in the pineal gland and the retina of the rat. Because the retina, pineal gland and Harderian gland (HG) serve analogous functions, we undertook a study to determine the presence of these peptides in these three organs of rats. They were detected by two specific methods: HPLC and specific radioimmunoassays. For Np, total neurophysins (NpT) were measured. To determine a 24 hr rhythm, the animals were maintained under a light/dark cycle of 12 hr/12 hr for 3 weeks. The pineal glands, retinae and HG were collected. Day/night rhythms of AVP, OT and NpT were demonstrated in the retina and HG; but the pineal gland had only AVP rhythm. A significant decrease in the rhythms at 4 a.m. was demonstrated in the retina and HG. The 24 hr variation of AVP in the retina seemed parallel to that of the HG.Entities:
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Year: 1988 PMID： 3375136 DOI： 10.1016/0196-9781(88)90262-8
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750