| Literature DB >> 33750813 |
Jennifer Barrila1,2, Shameema F Sarker2, Nicole Hansmeier3,4, Shanshan Yang5, Kristina Buss5, Natalia Briones5,6, Jin Park5, Richard R Davis1,2, Rebecca J Forsyth2, C Mark Ott7, Kevin Sato8, Cristine Kosnik9, Anthony Yang9, Cheryl Shimoda9, Nicole Rayl8,10, Diana Ly8, Aaron Landenberger11, Stephanie D Wilson12, Naoko Yamazaki13, Jason Steel5, Camila Montano5, Rolf U Halden14, Tom Cannon9, Sarah L Castro-Wallace7, Cheryl A Nickerson15,16,17.
Abstract
Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host-pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.Entities:
Year: 2021 PMID： 33750813 DOI： 10.1038/s41526-021-00136-w
Source DB: PubMed Journal: NPJ Microgravity ISSN： 2373-8065 Impact factor: 4.415