| Literature DB >> 33750787 |
Md Mahmudul Hasan1, Sumi Sukumaran Nair2, Jacqueline G O'Leary3, LuAnn Thompson-Snipes3, Verah Nyarige4, Junwen Wang4, Walter Park5, Mark Stegall5, Raymond Heilman2, Goran B Klintmalm3, HyeMee Joo6, SangKon Oh7.
Abstract
Regulatory B cells (Bregs) contribute to immune regulation. However, the mechanisms of action of Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM domains (TIGIT) expressed on human memory B cells especially CD19+CD24hiCD27+CD39hiIgD-IgM+CD1c+ B cells is essential for effective immune regulation. Mechanistically, TIGIT on memory B cells controls immune response by directly acting on T cells and by arresting proinflammatory function of dendritic cells, resulting in the suppression of Th1, Th2, Th17, and CXCR5+ICOS+ T cell response while promoting immune regulatory function of T cells. TIGIT+ memory B cells are also superior to other B cells at expressing additional inhibitory molecules, including IL-10, TGFβ1, granzyme B, PD-L1, CD39/CD73, and TIM-1. Lack or decrease of TIGIT+ memory B cells is associated with increased donor-specific antibody and TFH response, and decreased Treg response in renal and liver allograft patients. Therefore, TIGIT+ human memory B cells play critical roles in immune regulation.Entities:
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Year: 2021 PMID： 33750787 PMCID： PMC7943800 DOI： 10.1038/s41467-021-21413-y
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919