Sakarn Charoensakulchai1, Chaiyapun Lertpheantum2, Chanapon Aksornpusitpong2, Peeranut Trakulsuk2, Boonsub Sakboonyarat3, Ram Rangsin3, Mathirut Mungthin1, Phunlerd Piyaraj4. 1. Department of Parasitology, Phramongkutklao College of Medicine, 315, Rajawithee Rd, Thung Phyathai Sub-District, Rajadhewi District, Bangkok, 10400, Thailand. 2. Phramongkutklao College of Medicine, 315, Rajawithee Rd, Thung Phyathai Sub-District, Rajadhewi District, Bangkok, 10400, Thailand. 3. Department of Military and Community Medicine, Phramongkutklao College of Medicine, 315 Ratchawithee Rd, Chang Wat, Bangkok, 10400, Thailand. 4. Department of Parasitology, Phramongkutklao College of Medicine, 315, Rajawithee Rd, Thung Phyathai Sub-District, Rajadhewi District, Bangkok, 10400, Thailand. p_phunlerd@yahoo.com.
Abstract
OBJECTIVE: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow up) in a community hospital in Chachoengsao Province, Thailand from 1st January 2013 to 31st December 2019. RESULTS: A total of 487 patients were eligible for the study. The incidence of unsuccessful treatment was 21.67/100 population person year. Risk factors of unsuccessful pulmonary TB treatment were unemployment (adjusted hazard ratio (AHR) 3.12, 95%CI 1.41-6.86), HIV co-infection (AHR 2.85, 95%CI 1.25-6.46), previous history of TB (AHR 2.00, 95%CI 1.04-3.81), positive sputum AFB at the end of the intensive phase (AHR 5.66, 95%CI 2.33-13.74), and sputum AFB was not performed at the end of the intensive phase (AHR 18.40, 95%CI 9.85-34.35). This study can be utilized to improve prevention and intervention of TB treatment by strengthening public health system on treatment quality especially TB patient monitoring tools or methods easy for accessing to patients in communities.
OBJECTIVE:Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow up) in a community hospital in Chachoengsao Province, Thailand from 1st January 2013 to 31st December 2019. RESULTS: A total of 487 patients were eligible for the study. The incidence of unsuccessful treatment was 21.67/100 population person year. Risk factors of unsuccessful pulmonary TB treatment were unemployment (adjusted hazard ratio (AHR) 3.12, 95%CI 1.41-6.86), HIV co-infection (AHR 2.85, 95%CI 1.25-6.46), previous history of TB (AHR 2.00, 95%CI 1.04-3.81), positive sputum AFB at the end of the intensive phase (AHR 5.66, 95%CI 2.33-13.74), and sputum AFB was not performed at the end of the intensive phase (AHR 18.40, 95%CI 9.85-34.35). This study can be utilized to improve prevention and intervention of TB treatment by strengthening public health system on treatment quality especially TB patient monitoring tools or methods easy for accessing to patients in communities.
Authors: W M Jakubowiak; E M Bogorodskaya; S E Borisov; E S Borisov; I D Danilova; D I Danilova; E V Kourbatova; E K Kourbatova Journal: Int J Tuberc Lung Dis Date: 2007-01 Impact factor: 2.373
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Authors: Mahfuza Rifat; John Hall; Christopher Oldmeadow; Ashaque Husain; Sven Gudmund Hinderaker; Abul Hasnat Milton Journal: BMJ Open Date: 2015-09-08 Impact factor: 2.692