Chang Kyun Choi1, Jungho Yang2, Sun-Seog Kweon1, Sang-Hee Cho3, Hye-Yeon Kim4, Eun Myung5, Min-Ho Shin6. 1. Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Republic of Korea. 2. Graduate School of Public Health, Chonnam National University, Gwangju, Republic of Korea. 3. Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea. 4. Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Republic of Korea. 5. Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea. 6. Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Republic of Korea. mhshinx@paran.com.
Abstract
BACKGROUND: Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, presumably due to the high frequency of aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphisms. Nevertheless, the association between ALDH2 polymorphisms and esophageal cancer remains under debate. In the present study, we evaluated the association between ALDH2 rs671 polymorphisms and the risk of esophageal cancer in the South Korean population. METHODS: This study included 783 hospital based-cases and 8732 population-based controls. Information on smoking history and alcohol consumption was obtained from the medical records or interview questionnaires. Age-adjusted logistic regression analysis was performed to assess the association between ALDH2 rs671 polymorphisms and esophageal cancer. RESULTS: Odds ratios (ORs) for esophageal cancer in men with GA and AA genotypes were 2.75 (95% confidence interval [CI]: 2.34-3.23) and 0.08 (95% CI: 0.00-0.35), respectively; whereas, in women, these ratios were 2.99 (95% CI: 1.43-6.34) and 6.18 (95% CI: 1.40-19.62), respectively, taking subjects with the ALDH2 GG genotype as a reference. In men, the association between ALDH2 polymorphisms and esophageal cancer was modified by alcohol consumption. CONCLUSION: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation.
BACKGROUND:Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, presumably due to the high frequency of aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphisms. Nevertheless, the association between ALDH2 polymorphisms and esophageal cancer remains under debate. In the present study, we evaluated the association between ALDH2rs671 polymorphisms and the risk of esophageal cancer in the South Korean population. METHODS: This study included 783 hospital based-cases and 8732 population-based controls. Information on smoking history and alcohol consumption was obtained from the medical records or interview questionnaires. Age-adjusted logistic regression analysis was performed to assess the association between ALDH2rs671 polymorphisms and esophageal cancer. RESULTS: Odds ratios (ORs) for esophageal cancer in men with GA and AA genotypes were 2.75 (95% confidence interval [CI]: 2.34-3.23) and 0.08 (95% CI: 0.00-0.35), respectively; whereas, in women, these ratios were 2.99 (95% CI: 1.43-6.34) and 6.18 (95% CI: 1.40-19.62), respectively, taking subjects with the ALDH2 GG genotype as a reference. In men, the association between ALDH2 polymorphisms and esophageal cancer was modified by alcohol consumption. CONCLUSION: In Eastern Asians, ALDH2rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation.
Entities:
Keywords:
ALDH2; Alcohol drinking; Case-control studies; Esophageal cancer
Authors: Canqing Yu; Yu Guo; Zheng Bian; Ling Yang; Iona Y Millwood; Robin G Walters; Yiping Chen; Yan Chen; Xi Zhang; Yulong Lei; Junshi Chen; Zhengming Chen; Jun Lv; Liming Li Journal: Int J Cancer Date: 2018-06-11 Impact factor: 7.396
Authors: Iona Y Millwood; Robin G Walters; Xue W Mei; Yu Guo; Ling Yang; Zheng Bian; Derrick A Bennett; Yiping Chen; Caixia Dong; Ruying Hu; Gang Zhou; Bo Yu; Weifang Jia; Sarah Parish; Robert Clarke; George Davey Smith; Rory Collins; Michael V Holmes; Liming Li; Richard Peto; Zhengming Chen Journal: Lancet Date: 2019-04-04 Impact factor: 202.731