Literature DB >> 337488

Somatostatin: widespread abnormality in tissues of spontaneously diabetic mice.

Y C Patel, D P Cameron, Y Stefan, F Malaisse-Lagae, L Orci.   

Abstract

Diabetic mice of the C57BL/6J obob and C57BL/Ks dbdb strains show a reduction in pancreatic somatostatin concentration accompanied in the obob strain by a striking decrease in the number of somatostatin-containing cells in the islets. Somatostatin concentration is also decreased in the stomach but increased in the hypothalamus. These findings suggest different control mechanisms for somatostatin in the hypothalamus compared to the gut and pancreas and exclude a primary genetic abnormality of somatostatin cells in the mutants.

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Year:  1977        PMID： 337488     DOI： 10.1126/science.337488

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Virus-induced diabetes in mice: a quantitative evaluation of islet cell population by immunofluorescence technique.

Authors:  Y Stefan; F Malaisse-Lagae; J W Yoon; A L Notkins; L Orci
Journal:  Diabetologia       Date:  1978-11       Impact factor: 10.122

2.  Analysis of pancreatic islet cells and hormone content in the spontaneously diabetic KKAy mouse by morphometry, immunocytochemistry and radioimmunoassay.

Authors:  A R Diani; G A Sawada; B A Hannah; K S Jodelis; M A Connell; C L Connell; T J Vidmar; B M Wyse
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

3.  Pancreatic immunoreactive somatostatin and diabetes mellitus.

Authors:  A Ertan; A Arimura; K Akdamar; T Shibata; K Groot; M Luciano; F J Mather; H Degertekin; N Agrawal; J Ryan
Journal:  Dig Dis Sci       Date:  1984-07       Impact factor: 3.199

4.  Somatostatin content and release of isolated pancreatic islets from obese-hyperglycemic mice.

Authors:  B Petersson; G Lundqvist; A Andersson
Journal:  Experientia       Date:  1979-01-15

5.  Somatostatin in the pancreas and hypothalamus of obese mice.

Authors:  J Dolais-Kitabgi; Y Le Marchand-Brustel; P Freychet
Journal:  Diabetologia       Date:  1979-10       Impact factor: 10.122

6.  Pancreatic polypeptide and other hormones in pancreas of obese (ob/ob) mice.

Authors:  T Tomita; V Doull; J R Kimmel; H G Pollock
Journal:  Diabetologia       Date:  1984-10       Impact factor: 10.122

7.  Somatostatin release from dispersed hypothalamic cells: effects of diabetes.

Authors:  S B Richardson; S Twente
Journal:  Diabetologia       Date:  1987-11       Impact factor: 10.122
  7 in total

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