Heitor O Santos1, Carl J Lavie2. 1. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address: heitoroliveirasantos@gmail.com. 2. Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA.
Abstract
BACKGROUND & AIMS: The relationship between obesity, weight loss, and high-density lipoprotein cholesterol (HDL-C) is poorly recognized and understood. METHODS: Through an emphasis on current studies, in this viewpoint, we provide further scientific and medical considerations on the relationship between weight loss and the management of HDL-C levels. RESULTS: Long-term adherence to a low-calorie diet is a determinant of weight loss, with weight loss and/or normal weight being important clinical conditions to lower risk for the development of cardiometabolic dysregulations and cardiovascular diseases. These benefits appear to be independent of variations in serum lipids and lipoproteins. Indeed, there is a paradoxical link between weight loss and HDL-C levels, which can result in both increases and reductions in the concentrations of this recognized biomarker of cardiovascular health. CONCLUSIONS: Care should be exercised in order to avoid overvalued clinical recommendations in the management of HDL-C levels. Further hesitation is needed for health practitioners as well as skepticism surrounding science.
BACKGROUND & AIMS: The relationship between obesity, weight loss, and high-density lipoprotein cholesterol (HDL-C) is poorly recognized and understood. METHODS: Through an emphasis on current studies, in this viewpoint, we provide further scientific and medical considerations on the relationship between weight loss and the management of HDL-C levels. RESULTS: Long-term adherence to a low-calorie diet is a determinant of weight loss, with weight loss and/or normal weight being important clinical conditions to lower risk for the development of cardiometabolic dysregulations and cardiovascular diseases. These benefits appear to be independent of variations in serum lipids and lipoproteins. Indeed, there is a paradoxical link between weight loss and HDL-C levels, which can result in both increases and reductions in the concentrations of this recognized biomarker of cardiovascular health. CONCLUSIONS: Care should be exercised in order to avoid overvalued clinical recommendations in the management of HDL-C levels. Further hesitation is needed for health practitioners as well as skepticism surrounding science.
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