Literature DB >> 3374423

Effects of the heavy usage of kava on physical health: summary of a pilot survey in an aboriginal community.

J D Mathews1, M D Riley, L Fejo, E Munoz, N R Milns, I D Gardner, J R Powers, E Ganygulpa, B J Gununuwawuy.   

Abstract

Health status was assessed in 39 kava users and 34 non-users in a coastal Aboriginal community in Arnhem Land. Twenty (27%) respondents were very heavy (mean consumption, 440 g/week) users of kava; 15 (21%) respondents were heavy (310 g/week) users of kava and four (5%) respondents were occasional (100 g/week) users of kava. Kava users were more likely to complain of poor health and a "puffy" face, and were more likely to have a typical scaly rash, and slightly-increased patellar reflexes. Very heavy users of kava were 20% underweight and their levels of gamma-glutamyl transferase were increased greatly. Albumin, plasma protein, urea and bilirubin levels were decreased in kava users, and high-density lipoprotein cholesterol levels were increased. Kava users were more likely to show haematuria, and to have urine which was poorly acidified and of low specific gravity. The use of kava was also associated with an increased red-cell volume, with a decreased platelet volume and with a decreased lymphocyte count. Shortness of breath in kava users was associated with tall P waves on a resting electrocardiogram, which provided suggestive evidence of pulmonary hypertension. In common with other Aboriginal communities, there was evidence of decreased lung volumes, a high carriage rate of hepatitis B surface antigen, and of other morbidity that was unrelated to the use of kava. On the basis of these findings, there is a strong rationale for urgent social action to improve health in Aboriginal communities and, in particular, to reduce the consumption of kava and to improve the nutritional status of kava users.

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Year:  1988        PMID: 3374423     DOI: 10.5694/j.1326-5377.1988.tb93809.x

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  11 in total

1.  Hepatitis associated with Kava, a herbal remedy for anxiety.

Authors:  M Escher; J Desmeules; E Giostra; G Mentha
Journal:  BMJ       Date:  2001-01-20

2.  Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract.

Authors:  Natasha P Clayton; Katsuhiko Yoshizawa; Grace E Kissling; Leo T Burka; Po-Chuen Chan; Abraham Nyska
Journal:  Exp Toxicol Pathol       Date:  2006-10-23

3.  Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices.

Authors:  D Schmitz; C L Zhang; S S Chatterjee; U Heinemann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-04       Impact factor: 3.000

Review 4.  Therapeutic potential of kava in the treatment of anxiety disorders.

Authors:  Yadhu N Singh; Nirbhay N Singh
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

5.  Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited.

Authors:  Rolf Teschke; Jerome Sarris; Isaac Schweitzer
Journal:  Br J Clin Pharmacol       Date:  2012-02       Impact factor: 4.335

6.  A systematic review of the safety of kava extract in the treatment of anxiety.

Authors:  Clare Stevinson; Alyson Huntley; Edzard Ernst
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

7.  Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Authors:  Lei Guo; Qiang Shi; Stacey Dial; Qingsu Xia; Nan Mei; Quan-zhen Li; Po-Chuen Chan; Peter Fu
Journal:  Food Chem Toxicol       Date:  2009-12-03       Impact factor: 6.023

Review 8.  Toxicity of kava kava.

Authors:  Peter P Fu; Qingsu Xia; Lei Guo; Hongtao Yu; Po-Chuen Chan
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2008 Jan-Mar       Impact factor: 3.781

9.  In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice.

Authors:  Santanu Hati; Qi Hu; Zhiguang Huo; Junxuan Lu; Chengguo Xing
Journal:  ChemMedChem       Date:  2022-03-04       Impact factor: 3.540

Review 10.  Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.

Authors:  Flaminia Pantano; Roberta Tittarelli; Giulio Mannocchi; Simona Zaami; Serafino Ricci; Raffaele Giorgetti; Daniela Terranova; Francesco P Busardò; Enrico Marinelli
Journal:  Int J Mol Sci       Date:  2016-04-16       Impact factor: 5.923

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