Sanaz Alizadeh1, Shahideh Jahanian Sadatmahalleh1, Fatemeh Razavinia1, Mahnaz Bahri Khomami2, Malihe Nasiri3, Ashraf Moini4,5,6, Saeideh Ziaei7. 1. Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 1415-111, Dr. Saeideh Ziaei, Tehran, Iran. 2. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Vic, Australia. 3. Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Breast Disease Research Center (BDRC), School of Medicine, Tehran University of Medical Science, Tehran, Iran. 5. Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran. 6. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. 7. Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 1415-111, Dr. Saeideh Ziaei, Tehran, Iran. Ziaei_sa@modares.ac.ir.
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome. This study aimed to assess the metabolic parameters in the cord blood of neonate of mothers with obese PCOS and comparison with non-obese PCOS and controls. METHODS: This retrospective cohort study was conducted in Arash and Kamali Hospital in 2017-2018. The biochemical test was conducted on 78 neonates from obese PCOS mothers, 78 neonates from non-obese PCOS mothers, and 78 neonates from healthy mothers. Finally, cord blood lipid profile and insulin and blood sugar were determined by specific kits. Correlations between variables were compared with chi-square, Mann-Whitney's U, Kruskal-Wallis H tests and regression model by SPSS 23 and P < 0.05 was considered significant. RESULTS: Triglycerides (TG) and high-density lipoprotein cholesterol (HDL) were higher in cord blood of newborn of obese PCOS women than non-obese PCOS and controls (P = 0.02, P < 0.001, respectively). Also, the mean insulin was higher in cord blood of neonate of non-obese PCOS women than in obese PCOS and controls (12.26 ± 12.79 vs. 11.11 ± 16.51 vs. 6.21 ± 10.66, P = 0.01). But in the study, there was no significant difference between the mean of umbilical cord low-density lipoprotein cholesterol (LDL), total cholesterol and blood sugar in three groups. The logistic regression model showed that metabolic parameters were related to PCOS. CONCLUSIONS: In the present study, there was a significant difference between the mean of umbilical cord HDL, cholesterol, and the insulin level in the three groups. But, there was no significant association between the mean of blood sugar, LDL, and TG in the groups. The metabolic disorder in PCOS might affect cord blood lipid and insulin and adulthood health.
BACKGROUND:Polycystic ovary syndrome (PCOS) is characterized by reproductive disorder and increased risk of metabolic syndrome. This study aimed to assess the metabolic parameters in the cord blood of neonate of mothers with obese PCOS and comparison with non-obese PCOS and controls. METHODS: This retrospective cohort study was conducted in Arash and Kamali Hospital in 2017-2018. The biochemical test was conducted on 78 neonates from obese PCOS mothers, 78 neonates from non-obese PCOS mothers, and 78 neonates from healthy mothers. Finally, cord blood lipid profile and insulin and blood sugar were determined by specific kits. Correlations between variables were compared with chi-square, Mann-Whitney's U, Kruskal-Wallis H tests and regression model by SPSS 23 and P < 0.05 was considered significant. RESULTS:Triglycerides (TG) and high-density lipoprotein cholesterol (HDL) were higher in cord blood of newborn of obese PCOSwomen than non-obese PCOS and controls (P = 0.02, P < 0.001, respectively). Also, the mean insulin was higher in cord blood of neonate of non-obese PCOSwomen than in obese PCOS and controls (12.26 ± 12.79 vs. 11.11 ± 16.51 vs. 6.21 ± 10.66, P = 0.01). But in the study, there was no significant difference between the mean of umbilical cord low-density lipoprotein cholesterol (LDL), total cholesterol and blood sugar in three groups. The logistic regression model showed that metabolic parameters were related to PCOS. CONCLUSIONS: In the present study, there was a significant difference between the mean of umbilical cord HDL, cholesterol, and the insulin level in the three groups. But, there was no significant association between the mean of blood sugar, LDL, and TG in the groups. The metabolic disorder in PCOS might affect cord blood lipid and insulin and adulthood health.
Authors: Helen Anderson; Naomi Fogel; Stefan K Grebe; Ravinder J Singh; Robert L Taylor; Andrea Dunaif Journal: J Clin Endocrinol Metab Date: 2010-03-12 Impact factor: 5.958
Authors: William D Johnson; Jolanda J M Kroon; Frank L Greenway; Claude Bouchard; Donna Ryan; Peter T Katzmarzyk Journal: Arch Pediatr Adolesc Med Date: 2009-04
Authors: Naomi M Hamburg; Craig J McMackin; Alex L Huang; Sherene M Shenouda; Michael E Widlansky; Eberhard Schulz; Noyan Gokce; Neil B Ruderman; John F Keaney; Joseph A Vita Journal: Arterioscler Thromb Vasc Biol Date: 2007-10-11 Impact factor: 8.311