[Effect of artificial hyperglycemia and resection of the primary site on metastases of RL-67 carcinoma].

In the experiments on the C57Bl mice the authors studied the effect of artificial hyperglycemia (AH), amputation of the extremities with tumors as well as combinations of these effects on the intensity of metastatic spreading of carcinoma RL-67 to the lungs. AH did not prove to intensify the process of metastasizing if it was conducted on the 1, 3, 5, 7, 9 and 11th days. The average number of metastases did not differ from that in the control group. AH which was conducted one day before amputation of the extremity with the tumor caused a more significant inhibition of metastasizing than a surgical intervention.