Jatta Berberat1,2, Ruth Huggenberger3, Margherita Montali4,5, Philipp Gruber4, Achmed Pircher5, Karl-Olof Lövblad6, Hanspeter E Killer5, Luca Remonda4,7. 1. Department of Neuroradiology, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland. jatta.berberat@ksa.ch. 2. Department of Radiology and Medical Informatics, University of Geneva, 1202, Geneva, Switzerland. jatta.berberat@ksa.ch. 3. Praxisgemeinschaft Theaterplatz, 5400, Baden, Switzerland. 4. Department of Neuroradiology, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland. 5. Department of Ophthalmology, Kantonsspital Aarau, 5001, Aarau, Switzerland. 6. Department of Radiology and Medical Informatics, University of Geneva, 1202, Geneva, Switzerland. 7. University of Bern, 3011, Bern, Switzerland.
Abstract
BACKGROUND: Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching. METHODS: 45 subjects in three age-matched groups: (1) controls, (2) ADHD-adults under medication (ADHD+) and (3) medication-naïve adults with ADHD (ADHD-) underwent fMRI and neuropsychological testing. Group analysis and population-based statistics were performed. RESULTS: DTVP-A, intellectual ability as well as attention capability, visual-perceptual and visual-motor abilities showed no significant differences between the groups. However, fMRI revealed statistically significant differences between the ADHD+, ADHD- and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain regions, inferior fronto-frontal, fronto-cingulate and fronto-parietal networks as well as in the parietal lobe (p < 0.05). CONCLUSIONS: fMRI offers the potential to differentiate between the ADHD+, ADHD- and control groups. FMRI possibly opens a new window for monitoring the therapeutic effect of ADHD medication. TRIAL REGISTRATION: NCT02578342, registered at August 2015 to clinical trial registry ( https://ichgcp.net/clinical-trials-registry/NCT02578342 ).
BACKGROUND: Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching. METHODS: 45 subjects in three age-matched groups: (1) controls, (2) ADHD-adults under medication (ADHD+) and (3) medication-naïve adults with ADHD (ADHD-) underwent fMRI and neuropsychological testing. Group analysis and population-based statistics were performed. RESULTS: DTVP-A, intellectual ability as well as attention capability, visual-perceptual and visual-motor abilities showed no significant differences between the groups. However, fMRI revealed statistically significant differences between the ADHD+, ADHD- and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain regions, inferior fronto-frontal, fronto-cingulate and fronto-parietal networks as well as in the parietal lobe (p < 0.05). CONCLUSIONS: fMRI offers the potential to differentiate between the ADHD+, ADHD- and control groups. FMRI possibly opens a new window for monitoring the therapeutic effect of ADHD medication. TRIAL REGISTRATION: NCT02578342, registered at August 2015 to clinical trial registry ( https://ichgcp.net/clinical-trials-registry/NCT02578342 ).
Authors: G J DiGirolamo; A F Kramer; V Barad; N J Cepeda; D H Weissman; M P Milham; T M Wszalek; N J Cohen; M T Banich; A Webb; A V Belopolsky; E McAuley Journal: Neuroreport Date: 2001-07-03 Impact factor: 1.837
Authors: Ulrike M Krämer; Anne-Kristin Solbakk; Ingrid Funderud; Marianne Løvstad; Tor Endestad; Robert T Knight Journal: Cortex Date: 2012-05-15 Impact factor: 4.027