| Literature DB >> 33739254 |
Daniel J Grint1, Kevin Wing1, Elizabeth Williamson1, Helen I McDonald1, Krishnan Bhaskaran1, David Evans2, Stephen Jw Evans1, Alex J Walker2, George Hickman2, Emily Nightingale3, Anna Schultze1, Christopher T Rentsch1, Chris Bates4, Jonathan Cockburn4, Helen J Curtis2, Caroline E Morton2, Sebastian Bacon2, Simon Davy2, Angel Ys Wong1, Amir Mehrkar2, Laurie Tomlinson1, Ian J Douglas1, Rohini Mathur1, Paula Blomquist5, Brian MacKenna2, Peter Ingelsby2, Richard Croker2, John Parry4, Frank Hester4, Sam Harper4, Nicholas J DeVito2, Will Hulme2, John Tazare1, Ben Goldacre2,6, Liam Smeeth1,6, Rosalind M Eggo1,6.
Abstract
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.Entities:
Keywords: CFR; COVID-19; Case fatality risk; Coronavirus; Mortality; SARS-CoV-2; Variant of concern
Mesh：
Year: 2021 PMID： 33739254 PMCID： PMC7976383 DOI： 10.2807/1560-7917.ES.2021.26.11.2100256
Source DB: PubMed Journal: Euro Surveill ISSN： 1025-496X