Literature DB >> 33738371

Bitter Taste Receptors (T2Rs) are Sentinels that Coordinate Metabolic and Immunological Defense Responses.

Caroline P Harmon1, Daiyong Deng1, Paul A S Breslin1,2.   

Abstract

In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.

Entities:  

Keywords:  T2Rs; bitter taste; endocrine; homeostasis; hormones; immune; immunobiology; metabolism; regulatory physiology; sentinels

Year:  2021        PMID： 33738371      PMCID： PMC7963268          DOI： 10.1016/j.cophys.2021.01.006

Source DB:  PubMed          Journal:  Curr Opin Physiol        ISSN： 2468-8673


  53 in total

1.  Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis.

Authors:  Phillip R Purnell; Benjamin L Addicks; Habib G Zalzal; Scott Shapiro; Sijin Wen; Hassan H Ramadan; Vincent Setola; David P Siderovski
Journal:  Int Arch Allergy Immunol       Date:  2019-05-28       Impact factor: 2.749

Review 2.  The eating paradox: how we tolerate food.

Authors:  S C Woods
Journal:  Psychol Rev       Date:  1991-10       Impact factor: 8.934

3.  TAS2R bitter taste receptors regulate thyroid function.

Authors:  Adam A Clark; Cedrick D Dotson; Amanda E T Elson; Anja Voigt; Ulrich Boehm; Wolfgang Meyerhof; Nanette I Steinle; Steven D Munger
Journal:  FASEB J       Date:  2014-10-23       Impact factor: 5.191

4.  Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice.

Authors:  Junyan Li; Jie Xu; Ruifang Hou; Xin Jin; Jingyi Wang; Na Yang; Li Yang; Li Liu; Feng Tao; Hao Lu
Journal:  Biomed Pharmacother       Date:  2017-02-15       Impact factor: 6.529

5.  A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells.

Authors:  Hung Pham; Hongxiang Hui; Susan Morvaridi; Jiena Cai; Sanqi Zhang; Jun Tan; Vincent Wu; Nancy Levin; Beatrice Knudsen; William A Goddard; Stephen J Pandol; Ravinder Abrol
Journal:  Biochem Biophys Res Commun       Date:  2016-05-18       Impact factor: 3.575

6.  The Inclusive Behavioral Immune System.

Authors:  Keren Shakhar
Journal:  Front Psychol       Date:  2019-05-03

7.  Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates.

Authors:  Hiroo Imai; Miho Hakukawa; Misa Hayashi; Ken Iwatsuki; Katsuyoshi Masuda
Journal:  Int J Mol Sci       Date:  2020-01-30       Impact factor: 5.923

8.  Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers.

Authors:  E Deloose; M Corsetti; L Van Oudenhove; I Depoortere; J Tack
Journal:  Neurogastroenterol Motil       Date:  2017-08-04       Impact factor: 3.598

9.  Bitter taste receptors influence glucose homeostasis.

Authors:  Cedrick D Dotson; Lan Zhang; Hong Xu; Yu-Kyong Shin; Stephan Vigues; Sandra H Ott; Amanda E T Elson; Hyun Jin Choi; Hillary Shaw; Josephine M Egan; Braxton D Mitchell; Xiaodong Li; Nanette I Steinle; Steven D Munger
Journal:  PLoS One       Date:  2008-12-18       Impact factor: 3.240

10.  Gingival solitary chemosensory cells are immune sentinels for periodontitis.

Authors:  Xin Zheng; Marco Tizzano; Kevin Redding; Jinzhi He; Xian Peng; Peihua Jiang; Xin Xu; Xuedong Zhou; Robert F Margolskee
Journal:  Nat Commun       Date:  2019-10-03       Impact factor: 14.919
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  6 in total

1.  Cilia Stimulatory and Antibacterial Activities of T2R Bitter Taste Receptor Agonist Diphenhydramine: Insights into Repurposing Bitter Drugs for Nasal Infections.

Authors:  Li Eon Kuek; Derek B McMahon; Ray Z Ma; Zoey A Miller; Jennifer F Jolivert; Nithin D Adappa; James N Palmer; Robert J Lee
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-06

Review 2.  Taste Receptors: The Gatekeepers of the Airway Epithelium.

Authors:  Katleen Martens; Brecht Steelant; Dominique M A Bullens
Journal:  Cells       Date:  2021-10-26       Impact factor: 6.600

Review 3.  Tuft cell integration of luminal states and interaction modules in tissues.

Authors:  Christoph Schneider
Journal:  Pflugers Arch       Date:  2021-10-11       Impact factor: 3.657

4.  Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.

Authors:  Daichi Kobayashi; Tomoya Watarai; Madoka Ozawa; Yasuhiro Kanda; Fumihiro Saika; Norikazu Kiguchi; Arata Takeuchi; Masahito Ikawa; Shinsuke Matsuzaki; Tomoya Katakai
Journal:  Front Immunol       Date:  2022-08-18       Impact factor: 8.786

5.  Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39.

Authors:  Gabriella Morini; Marcel Winnig; Timo Vennegeerts; Gigliola Borgonovo; Angela Bassoli
Journal:  Front Nutr       Date:  2021-07-09

6.  Effect of Welsh Onion on Taste Components and Sensory Characteristics of Porcine Bone Soup.

Authors:  Li Liang; Chenchen Zhou; Yuyu Zhang; Baoguo Sun
Journal:  Foods       Date:  2021-12-02
  6 in total

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