Meichen Wang1, Timothy D Phillips1. 1. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Abstract
OBJECTIVE: Polychlorinated biphenyls (PCBs) are lipophilic and persistent environmental pollutants that are readily absorbed and accumulated in high concentrations in fatty tissues of humans and animals. Invertebrate animals, such as oysters, are vulnerable and sensitive to PCB contamination. METHODS: Previously, our in vitro isothermal studies have shown that acid processed montmorillonites (APM) can effectively bind PCBs and Aroclors. Therefore, in a novel application of this work, a dietary strategy for shellfish was developed using APM, and its parent clay to reduce exposures to PCBs in oysters. PCB residues in oysters with clay treatment at different dietary inclusion rates and durations were measured and compared to a washout treatment. RESULTS: The efficacy and safety of this strategy were supported by a significant reduction of PCB residues with the inclusion of a low level of APM (0.05%) during a 4-day treatment. Moreover, this sorbent strategy reduced PCB residues in oysters in a dose- and time-dependent manner. CONCLUSIONS: Based on our results, it is possible that clay-based sorbents such as APM, can be included in the diet to significantly reduce exposures to PCBs.
OBJECTIVE: Polychlorinated biphenyls (PCBs) are lipophilic and persistent environmental pollutants that are readily absorbed and accumulated in high concentrations in fatty tissues of humans and animals. Invertebrate animals, such as oysters, are vulnerable and sensitive to PCB contamination. METHODS: Previously, our in vitro isothermal studies have shown that acid processed montmorillonites (APM) can effectively bind PCBs and Aroclors. Therefore, in a novel application of this work, a dietary strategy for shellfish was developed using APM, and its parent clay to reduce exposures to PCBs in oysters. PCB residues in oysters with clay treatment at different dietary inclusion rates and durations were measured and compared to a washout treatment. RESULTS: The efficacy and safety of this strategy were supported by a significant reduction of PCB residues with the inclusion of a low level of APM (0.05%) during a 4-day treatment. Moreover, this sorbent strategy reduced PCB residues in oysters in a dose- and time-dependent manner. CONCLUSIONS: Based on our results, it is possible that clay-based sorbents such as APM, can be included in the diet to significantly reduce exposures to PCBs.
Authors: Rafael Trevisan; Fabrício Flores-Nunes; Euler S Dolores; Jacó J Mattos; Clei E Piazza; Sílvio T Sasaki; Satie Taniguchi; Rosalinda C Montone; Márcia C Bícego; Isis M M Dos Reis; Flávia L Zacchi; Bárbara N M Othero; Camila L V Bastolla; Danielle F Mello; Ana Paula M Fraga; Nestor Wendt; Guilherme Toledo-Silva; Guilherme Razzera; Alcir L Dafre; Cláudio M R de Melo; Adalto Bianchini; Maria R F Marques; Afonso C D Bainy Journal: Environ Toxicol Chem Date: 2016-08-12 Impact factor: 3.742
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