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Literature DB >> 33737725

Targeted protein degraders crowd into the clinic.

Asher Mullard.

Abstract

Year: 2021 PMID： 33737725 DOI： 10.1038/d41573-021-00052-4

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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34 in total

Review 1. The PROTACtable genome.

Authors: Melanie Schneider; Chris J Radoux; Andrew Hercules; David Ochoa; Ian Dunham; Lykourgos-Panagiotis Zalmas; Gerhard Hessler; Sven Ruf; Veerabahu Shanmugasundaram; Michael M Hann; Pam J Thomas; Markus A Queisser; Andrew B Benowitz; Kris Brown; Andrew R Leach
Journal: Nat Rev Drug Discov Date: 2021-07-20 Impact factor: 84.694

2. Circular RNAs With Efficacy in Preclinical In Vitro and In Vivo Models of Esophageal Squamous Cell Carcinoma.

Authors: Ulrich H Weidle; Tatjana Sela; Ulrich Brinkmann; Jens Niewoehner
Journal: Cancer Genomics Proteomics Date: 2022 May-Jun Impact factor: 4.069

3. Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras.

Authors: He Chen; Jing Liu; H Ümit Kaniskan; Wenyi Wei; Jian Jin
Journal: J Med Chem Date: 2021-08-11 Impact factor: 8.039

4. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.

Authors: Chetan K Chana; Pierre Maisonneuve; Ganna Posternak; Nicolas G A Grinberg; Juline Poirson; Samara M Ona; Derek F Ceccarelli; Pavel Mader; Daniel J St-Cyr; Victor Pau; Igor Kurinov; Xiaojing Tang; Dongjing Deng; Weiren Cui; Wenji Su; Letian Kuai; Richard Soll; Mike Tyers; Hannes L Röst; Robert A Batey; Mikko Taipale; Anne-Claude Gingras; Frank Sicheri
Journal: J Med Chem Date: 2022-09-18 Impact factor: 8.039

Review 5. Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges.

Authors: Chao Wang; Yujing Zhang; Tingting Zhang; Lingyu Shi; Zhongmin Geng; Dongming Xing
Journal: J Enzyme Inhib Med Chem Date: 2022-12 Impact factor: 5.756

Targeted protein degraders crowd into the clinic.

Review 1. The PROTACtable genome.

2. Circular RNAs With Efficacy in Preclinical In Vitro and In Vivo Models of Esophageal Squamous Cell Carcinoma.

3. Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras.

4. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.

Review 5. Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges.

6. Structure-based assessment and druggability classification of protein-protein interaction sites.

7. Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation.

8. Estimating the cooperativity of PROTAC-induced ternary complexes using ¹⁹F NMR displacement assay.

9. A platform for the rapid synthesis of proteolysis targeting chimeras (Rapid-TAC) under miniaturized conditions.

10. PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.