Literature DB >> 33737297

Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium.

Chun-Han Lo1,2,3, William J Blot4, Lauren R Teras5, Kala Visvanathan6, Loïc Le Marchand7, Christopher A Haiman8, Yu Chen9, Howard D Sesso3,10, Sylvia Wassertheil-Smoller11, Lesley F Tinker12, Richard M Peek13, John D Potter14, Timothy L Cover15, Anne Zeleniuch-Jacquotte9, Sonja I Berndt16, Tim Waterboer17, Meira Epplein18, Julia Butt17,18, Mingyang Song19,2,3,20.   

Abstract

BACKGROUND: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established.
METHODS: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States.
RESULTS: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk.
CONCLUSIONS: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. IMPACT: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples. ©2021 American Association for Cancer Research.

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Year:  2021        PMID: 33737297      PMCID: PMC8172443          DOI: 10.1158/1055-9965.EPI-20-1471

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  8 in total

1.  Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.

Authors:  Vinayak Kapatral; Iain Anderson; Natalia Ivanova; Gary Reznik; Tamara Los; Athanasios Lykidis; Anamitra Bhattacharyya; Allen Bartman; Warren Gardner; Galina Grechkin; Lihua Zhu; Olga Vasieva; Lien Chu; Yakov Kogan; Oleg Chaga; Eugene Goltsman; Axel Bernal; Niels Larsen; Mark D'Souza; Theresa Walunas; Gordon Pusch; Robert Haselkorn; Michael Fonstein; Nikos Kyrpides; Ross Overbeek
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

Review 2.  Health disparities in colorectal cancer among racial and ethnic minorities in the United States.

Authors:  Christian S Jackson; Matthew Oman; Aatish M Patel; Kenneth J Vega
Journal:  J Gastrointest Oncol       Date:  2016-04

3.  Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer.

Authors:  Julia Butt; Mazda Jenab; Tim Waterboer; David J Hughes; Michael Pawlita; Kim Overvad; Anne Tjonneland; Anja Olsen; Marie-Christine Boutron-Ruault; Franck Carbonnel; Francesca Romana Mancini; Rudolf Kaaks; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Anna Karakatsani; Domenico Palli; Valeria Maria Pala; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Bas Bueno-de-Mesquita; Carla H van Gils; Roel C H Vermeulen; Elisabete Weiderpass; José Ramón Quirós; Eric Jeffrey Duell; Maria-Jose Sánchez; Miren Dorronsoro; José María Huerta; Eva Ardanaz; Bethany Van Guelpen; Sophia Harlid; Aurora Perez-Cornago; Marc J Gunter; Neil Murphy; Heinz Freisling; Dagfinn Aune
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2019-09       Impact factor: 4.254

Review 4.  Socioeconomic position indicators and periodontitis: examining the evidence.

Authors:  Luisa N Borrell; Natalie D Crawford
Journal:  Periodontol 2000       Date:  2012-02       Impact factor: 7.589

Review 5.  Fusobacterium nucleatum - symbiont, opportunist and oncobacterium.

Authors:  Caitlin A Brennan; Wendy S Garrett
Journal:  Nat Rev Microbiol       Date:  2019-03       Impact factor: 60.633

6.  Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States.

Authors:  Julia Butt; Matthew G Varga; William J Blot; Lauren Teras; Kala Visvanathan; Loïc Le Marchand; Christopher Haiman; Yu Chen; Ying Bao; Howard D Sesso; Sylvia Wassertheil-Smoller; Gloria Y F Ho; Lesley E Tinker; Richard M Peek; John D Potter; Timothy L Cover; Laura H Hendrix; Li-Ching Huang; Terry Hyslop; Caroline Um; Francine Grodstein; Mingyang Song; Anne Zeleniuch-Jacquotte; Sonja Berndt; Allan Hildesheim; Tim Waterboer; Michael Pawlita; Meira Epplein
Journal:  Gastroenterology       Date:  2018-10-06       Impact factor: 22.682

7.  Is antibiotics use really associated with increased risk of colorectal cancer? An updated systematic review and meta-analysis of observational studies.

Authors:  Guangbo Qu; Chenyu Sun; Monica Sharma; John Patrick Uy; Evelyn J Song; Chandur Bhan; Liqin Shu
Journal:  Int J Colorectal Dis       Date:  2020-06-06       Impact factor: 2.571

8.  Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer.

Authors:  Hai-Fang Wang; Lin-Fang Li; Song-He Guo; Qiu-Yao Zeng; Fen Ning; Wan-Li Liu; Ge Zhang
Journal:  Sci Rep       Date:  2016-09-28       Impact factor: 4.379

  8 in total

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