Literature DB >> 33737296

Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk.

Derek W Brown1,2, Qing Lan3, Nathaniel Rothman3, John Pluta4, Kristian Almstrup5, Marlene D Dalgaard6, Mark H Greene3, Tom Grotmol7, Chey Loveday8, Stephen M Schwartz9,10, Clare Turnbull8,11, Fredrik Wiklund12, Peter A Kanetsky13, Katherine L Nathanson4,14, Katherine A McGlynn, Mitchell J Machiela3.   

Abstract

BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.
METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk. IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk. ©2021 American Association for Cancer Research.

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Year:  2021        PMID: 33737296      PMCID: PMC8172526          DOI: 10.1158/1055-9965.EPI-20-1775

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.090


  6 in total

Review 1.  Telomeres and telomerase in cancer.

Authors:  Steven E Artandi; Ronald A DePinho
Journal:  Carcinogenesis       Date:  2009-11-03       Impact factor: 4.944

2.  Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia.

Authors:  Mitchell J Machiela; Chao Agnes Hsiung; Xiao-Ou Shu; Wei Jie Seow; Zhaoming Wang; Keitaro Matsuo; Yun-Chul Hong; Adeline Seow; Chen Wu; H Dean Hosgood; Kexin Chen; Jiu-Cun Wang; Wanqing Wen; Richard Cawthon; Nilanjan Chatterjee; Wei Hu; Neil E Caporaso; Jae Yong Park; Chien-Jen Chen; Yeul Hong Kim; Young Tae Kim; Maria Teresa Landi; Hongbing Shen; Charles Lawrence; Laurie Burdett; Meredith Yeager; I-Shou Chang; Tetsuya Mitsudomi; Hee Nam Kim; Gee-Chen Chang; Bryan A Bassig; Margaret Tucker; Fusheng Wei; Zhihua Yin; She-Juan An; Biyun Qian; Victor Ho Fun Lee; Daru Lu; Jianjun Liu; Hyo-Sung Jeon; Chin-Fu Hsiao; Jae Sook Sung; Jin Hee Kim; Yu-Tang Gao; Ying-Huang Tsai; Yoo Jin Jung; Huan Guo; Zhibin Hu; Amy Hutchinson; Wen-Chang Wang; Robert J Klein; Charles C Chung; In-Jae Oh; Kuan-Yu Chen; Sonja I Berndt; Wei Wu; Jiang Chang; Xu-Chao Zhang; Ming-Shyan Huang; Hong Zheng; Junwen Wang; Xueying Zhao; Yuqing Li; Jin Eun Choi; Wu-Chou Su; Kyong Hwa Park; Sook Whan Sung; Yuh-Min Chen; Li Liu; Chang Hyun Kang; Lingmin Hu; Chung-Hsing Chen; William Pao; Young-Chul Kim; Tsung-Ying Yang; Jun Xu; Peng Guan; Wen Tan; Jian Su; Chih-Liang Wang; Haixin Li; Alan Dart Loon Sihoe; Zhenhong Zhao; Ying Chen; Yi Young Choi; Jen-Yu Hung; Jun Suk Kim; Ho-Il Yoon; Qiuyin Cai; Chien-Chung Lin; In Kyu Park; Ping Xu; Jing Dong; Christopher Kim; Qincheng He; Reury-Perng Perng; Takashi Kohno; Sun-Seog Kweon; Chih-Yi Chen; Roel C H Vermeulen; Junjie Wu; Wei-Yen Lim; Kun-Chieh Chen; Wong-Ho Chow; Bu-Tian Ji; John K C Chan; Minjie Chu; Yao-Jen Li; Jun Yokota; Jihua Li; Hongyan Chen; Yong-Bing Xiang; Chong-Jen Yu; Hideo Kunitoh; Guoping Wu; Li Jin; Yen-Li Lo; Kouya Shiraishi; Ying-Hsiang Chen; Hsien-Chih Lin; Tangchun Wu; Maria Pik Wong; Yi-Long Wu; Pan-Chyr Yang; Baosen Zhou; Min-Ho Shin; Joseph F Fraumeni; Wei Zheng; Dongxin Lin; Stephen J Chanock; Nathaniel Rothman; Qing Lan
Journal:  Int J Cancer       Date:  2014-12-29       Impact factor: 7.396

3.  Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:  Philip C Haycock; Stephen Burgess; Aayah Nounu; Jie Zheng; George N Okoli; Jack Bowden; Kaitlin Hazel Wade; Nicholas J Timpson; David M Evans; Peter Willeit; Abraham Aviv; Tom R Gaunt; Gibran Hemani; Massimo Mangino; Hayley Patricia Ellis; Kathreena M Kurian; Karen A Pooley; Rosalind A Eeles; Jeffrey E Lee; Shenying Fang; Wei V Chen; Matthew H Law; Lisa M Bowdler; Mark M Iles; Qiong Yang; Bradford B Worrall; Hugh Stephen Markus; Rayjean J Hung; Chris I Amos; Amanda B Spurdle; Deborah J Thompson; Tracy A O'Mara; Brian Wolpin; Laufey Amundadottir; Rachael Stolzenberg-Solomon; Antonia Trichopoulou; N Charlotte Onland-Moret; Eiliv Lund; Eric J Duell; Federico Canzian; Gianluca Severi; Kim Overvad; Marc J Gunter; Rosario Tumino; Ulrika Svenson; Andre van Rij; Annette F Baas; Matthew J Bown; Nilesh J Samani; Femke N G van t'Hof; Gerard Tromp; Gregory T Jones; Helena Kuivaniemi; James R Elmore; Mattias Johansson; James Mckay; Ghislaine Scelo; Robert Carreras-Torres; Valerie Gaborieau; Paul Brennan; Paige M Bracci; Rachel E Neale; Sara H Olson; Steven Gallinger; Donghui Li; Gloria M Petersen; Harvey A Risch; Alison P Klein; Jiali Han; Christian C Abnet; Neal D Freedman; Philip R Taylor; John M Maris; Katja K Aben; Lambertus A Kiemeney; Sita H Vermeulen; John K Wiencke; Kyle M Walsh; Margaret Wrensch; Terri Rice; Clare Turnbull; Kevin Litchfield; Lavinia Paternoster; Marie Standl; Gonçalo R Abecasis; John Paul SanGiovanni; Yong Li; Vladan Mijatovic; Yadav Sapkota; Siew-Kee Low; Krina T Zondervan; Grant W Montgomery; Dale R Nyholt; David A van Heel; Karen Hunt; Dan E Arking; Foram N Ashar; Nona Sotoodehnia; Daniel Woo; Jonathan Rosand; Mary E Comeau; W Mark Brown; Edwin K Silverman; John E Hokanson; Michael H Cho; Jennie Hui; Manuel A Ferreira; Philip J Thompson; Alanna C Morrison; Janine F Felix; Nicholas L Smith; Angela M Christiano; Lynn Petukhova; Regina C Betz; Xing Fan; Xuejun Zhang; Caihong Zhu; Carl D Langefeld; Susan D Thompson; Feijie Wang; Xu Lin; David A Schwartz; Tasha Fingerlin; Jerome I Rotter; Mary Frances Cotch; Richard A Jensen; Matthias Munz; Henrik Dommisch; Arne S Schaefer; Fang Han; Hanna M Ollila; Ryan P Hillary; Omar Albagha; Stuart H Ralston; Chenjie Zeng; Wei Zheng; Xiao-Ou Shu; Andre Reis; Steffen Uebe; Ulrike Hüffmeier; Yoshiya Kawamura; Takeshi Otowa; Tsukasa Sasaki; Martin Lloyd Hibberd; Sonia Davila; Gang Xie; Katherine Siminovitch; Jin-Xin Bei; Yi-Xin Zeng; Asta Försti; Bowang Chen; Stefano Landi; Andre Franke; Annegret Fischer; David Ellinghaus; Carlos Flores; Imre Noth; Shwu-Fan Ma; Jia Nee Foo; Jianjun Liu; Jong-Won Kim; David G Cox; Olivier Delattre; Olivier Mirabeau; Christine F Skibola; Clara S Tang; Merce Garcia-Barcelo; Kai-Ping Chang; Wen-Hui Su; Yu-Sun Chang; Nicholas G Martin; Scott Gordon; Tracey D Wade; Chaeyoung Lee; Michiaki Kubo; Pei-Chieng Cha; Yusuke Nakamura; Daniel Levy; Masayuki Kimura; Shih-Jen Hwang; Steven Hunt; Tim Spector; Nicole Soranzo; Ani W Manichaikul; R Graham Barr; Bratati Kahali; Elizabeth Speliotes; Laura M Yerges-Armstrong; Ching-Yu Cheng; Jost B Jonas; Tien Yin Wong; Isabella Fogh; Kuang Lin; John F Powell; Kenneth Rice; Caroline L Relton; Richard M Martin; George Davey Smith
Journal:  JAMA Oncol       Date:  2017-05-01       Impact factor: 31.777

4.  Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Authors:  Mitchell J Machiela; Jonathan N Hofmann; Robert Carreras-Torres; Kevin M Brown; Mattias Johansson; Zhaoming Wang; Matthieu Foll; Peng Li; Nathaniel Rothman; Sharon A Savage; Valerie Gaborieau; James D McKay; Yuanqing Ye; Marc Henrion; Fiona Bruinsma; Susan Jordan; Gianluca Severi; Kristian Hveem; Lars J Vatten; Tony Fletcher; Kvetoslava Koppova; Susanna C Larsson; Alicja Wolk; Rosamonde E Banks; Peter J Selby; Douglas F Easton; Paul Pharoah; Gabriella Andreotti; Laura E Beane Freeman; Stella Koutros; Demetrius Albanes; Satu Mannisto; Stephanie Weinstein; Peter E Clark; Todd E Edwards; Loren Lipworth; Susan M Gapstur; Victoria L Stevens; Hallie Carol; Matthew L Freedman; Mark M Pomerantz; Eunyoung Cho; Peter Kraft; Mark A Preston; Kathryn M Wilson; J Michael Gaziano; Howard S Sesso; Amanda Black; Neal D Freedman; Wen-Yi Huang; John G Anema; Richard J Kahnoski; Brian R Lane; Sabrina L Noyes; David Petillo; Leandro M Colli; Joshua N Sampson; Celine Besse; Helene Blanche; Anne Boland; Laurie Burdette; Egor Prokhortchouk; Konstantin G Skryabin; Meredith Yeager; Mirjana Mijuskovic; Miodrag Ognjanovic; Lenka Foretova; Ivana Holcatova; Vladimir Janout; Dana Mates; Anush Mukeriya; Stefan Rascu; David Zaridze; Vladimir Bencko; Cezary Cybulski; Eleonora Fabianova; Viorel Jinga; Jolanta Lissowska; Jan Lubinski; Marie Navratilova; Peter Rudnai; Neonila Szeszenia-Dabrowska; Simone Benhamou; Geraldine Cancel-Tassin; Olivier Cussenot; H Bas Bueno-de-Mesquita; Federico Canzian; Eric J Duell; Börje Ljungberg; Raviprakash T Sitaram; Ulrike Peters; Emily White; Garnet L Anderson; Lisa Johnson; Juhua Luo; Julie Buring; I-Min Lee; Wong-Ho Chow; Lee E Moore; Christopher Wood; Timothy Eisen; James Larkin; Toni K Choueiri; G Mark Lathrop; Bin Tean Teh; Jean-Francois Deleuze; Xifeng Wu; Richard S Houlston; Paul Brennan; Stephen J Chanock; Ghislaine Scelo; Mark P Purdue
Journal:  Eur Urol       Date:  2017-08-07       Impact factor: 20.096

5.  Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.

Authors:  Zhaoming Wang; Katherine A McGlynn; Ewa Rajpert-De Meyts; D Timothy Bishop; Charles C Chung; Marlene D Dalgaard; Mark H Greene; Ramneek Gupta; Tom Grotmol; Trine B Haugen; Robert Karlsson; Kevin Litchfield; Nandita Mitra; Kasper Nielsen; Louise C Pyle; Stephen M Schwartz; Vésteinn Thorsson; Saran Vardhanabhuti; Fredrik Wiklund; Clare Turnbull; Stephen J Chanock; Peter A Kanetsky; Katherine L Nathanson
Journal:  Nat Genet       Date:  2017-06-12       Impact factor: 38.330

6.  Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.

Authors:  Chen Li; Svetlana Stoma; Luca A Lotta; Sophie Warner; Eva Albrecht; Alessandra Allione; Pascal P Arp; Linda Broer; Jessica L Buxton; Alexessander Da Silva Couto Alves; Joris Deelen; Iryna O Fedko; Scott D Gordon; Tao Jiang; Robert Karlsson; Nicola Kerrison; Taylor K Loe; Massimo Mangino; Yuri Milaneschi; Benjamin Miraglio; Natalia Pervjakova; Alessia Russo; Ida Surakka; Ashley van der Spek; Josine E Verhoeven; Najaf Amin; Marian Beekman; Alexandra I Blakemore; Federico Canzian; Stephen E Hamby; Jouke-Jan Hottenga; Peter D Jones; Pekka Jousilahti; Reedik Mägi; Sarah E Medland; Grant W Montgomery; Dale R Nyholt; Markus Perola; Kirsi H Pietiläinen; Veikko Salomaa; Elina Sillanpää; H Eka Suchiman; Diana van Heemst; Gonneke Willemsen; Antonio Agudo; Heiner Boeing; Dorret I Boomsma; Maria-Dolores Chirlaque; Guy Fagherazzi; Pietro Ferrari; Paul Franks; Christian Gieger; Johan Gunnar Eriksson; Marc Gunter; Sara Hägg; Iiris Hovatta; Liher Imaz; Jaakko Kaprio; Rudolf Kaaks; Timothy Key; Vittorio Krogh; Nicholas G Martin; Olle Melander; Andres Metspalu; Concha Moreno; N Charlotte Onland-Moret; Peter Nilsson; Ken K Ong; Kim Overvad; Domenico Palli; Salvatore Panico; Nancy L Pedersen; Brenda W J H Penninx; J Ramón Quirós; Marjo Riitta Jarvelin; Miguel Rodríguez-Barranco; Robert A Scott; Gianluca Severi; P Eline Slagboom; Tim D Spector; Anne Tjonneland; Antonia Trichopoulou; Rosario Tumino; André G Uitterlinden; Yvonne T van der Schouw; Cornelia M van Duijn; Elisabete Weiderpass; Eros Lazzerini Denchi; Giuseppe Matullo; Adam S Butterworth; John Danesh; Nilesh J Samani; Nicholas J Wareham; Christopher P Nelson; Claudia Langenberg; Veryan Codd
Journal:  Am J Hum Genet       Date:  2020-02-27       Impact factor: 11.025

  6 in total
  1 in total

1.  Predicted leukocyte telomere length and risk of germ cell tumours.

Authors:  Shannon S Cigan; John J Meredith; Ava C Kelley; Tianzhong Yang; Erica K Langer; Anthony J Hooten; John A Lane; Benjamin R Cole; Mark Krailo; A Lindsay Frazier; Nathan Pankratz; Jenny N Poynter
Journal:  Br J Cancer       Date:  2022-04-02       Impact factor: 9.075

  1 in total

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