OBJECTIVES: Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which is closely related to the poor prognosis of patients. We aimed to explore potential risk factors and outcomes associated with early post-operative AKI after LTx. METHODS: A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 to 2019. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate and multivariate analyses were conducted to identify risk factors related to AKI. The primary outcome was the incidence of AKI after LTx. Secondary outcomes were associations between AKI and short-term clinical outcomes and mortality. RESULTS: Of the 136 patients analyzed, 110 developed AKI (80.9%). AKI was associated with higher baseline eGFR (odds ratio (OR) 1.01 (95% confidence interval (CI): 1.00-1.03)) and median tacrolimus (TAC) concentration (OR 1.15 (95% CI: 1.02-1.30)). Patients with AKI suffered longer mechanical ventilation days (p = .015) and ICU stay days (p = .011). AKI stage 2-3 patients had higher risk of 1-year mortality (HR 16.98 (95% CI: 2.25-128.45)) compared with no-AKI and stage 1 patients. CONCLUSIONS: Our results suggested early post-operative AKI may be associated with higher baseline eGFR and TAC concentrations. AKI stage 1 may have no influence on survival rate, whereas AKI stage 2-3 may be associated with increased mortality at 1-year.
OBJECTIVES: Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which is closely related to the poor prognosis of patients. We aimed to explore potential risk factors and outcomes associated with early post-operative AKI after LTx. METHODS: A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 to 2019. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate and multivariate analyses were conducted to identify risk factors related to AKI. The primary outcome was the incidence of AKI after LTx. Secondary outcomes were associations between AKI and short-term clinical outcomes and mortality. RESULTS: Of the 136 patients analyzed, 110 developed AKI (80.9%). AKI was associated with higher baseline eGFR (odds ratio (OR) 1.01 (95% confidence interval (CI): 1.00-1.03)) and median tacrolimus (TAC) concentration (OR 1.15 (95% CI: 1.02-1.30)). Patients with AKI suffered longer mechanical ventilation days (p = .015) and ICU stay days (p = .011). AKI stage 2-3 patients had higher risk of 1-year mortality (HR 16.98 (95% CI: 2.25-128.45)) compared with no-AKI and stage 1 patients. CONCLUSIONS: Our results suggested early post-operative AKI may be associated with higher baseline eGFR and TAC concentrations. AKI stage 1 may have no influence on survival rate, whereas AKI stage 2-3 may be associated with increased mortality at 1-year.
Authors: Daniel R Calabrese; Rebecca Florez; Katherine Dewey; Christine Hui; Dara Torgerson; Tiffany Chong; Hilary Faust; Raja Rajalingam; Steven R Hays; Jeffrey A Golden; Jasleen Kukreja; Jonathan P Singer; John R Greenland Journal: Clin Transplant Date: 2018-07-04 Impact factor: 2.863
Authors: Albert P Nguyen; Rodney A Gabriel; Eugene Golts; Erik B Kistler; Ulrich Schmidt Journal: J Cardiothorac Vasc Anesth Date: 2017-02-05 Impact factor: 2.628
Authors: E Atchade; S Barour; A Tran-Dinh; S Jean-Baptiste; S Tanaka; P Tashk; A Snauwaert; B Lortat-Jacob; G Mourin; P Mordant; Y Castier; H Mal; C De Tymowski; P Montravers Journal: Transplant Proc Date: 2020-03-07 Impact factor: 1.066
Authors: Jeong Ho Kim; Young Soo Kim; Min Seok Choi; Young Ok Kim; Sun Ae Yoon; Ji-Il Kim; In Sung Moon; Bum Soon Choi; Cheol Whee Park; Chul Woo Yang; Yong-Soo Kim; Byung Ha Chung Journal: BMC Nephrol Date: 2017-01-27 Impact factor: 2.388