Literature DB >> 3373550

Tumor necrosis factor not detectable in patients with clinical cancer cachexia.

S H Socher1, D Martinez, J B Craig, J G Kuhn, A Oliff.   

Abstract

Tumor necrosis factor (TNF) has been implicated in the pathogenesis of cachexia in neoplastic and infectious diseases. To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%-40% of premorbid weight. The weight loss experienced by these patients was not attributable to anticancer therapy, gastrointestinal disorders, or other medical problems. TNF was measured using a quantitative sandwich enzyme-linked immunosorbent assay that is sensitive to human TNF in serum at concentrations greater than or equal to 40 pg/mL. No TNF was detected in serum samples from the 19 patients studied.

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Year:  1988        PMID： 3373550     DOI： 10.1093/jnci/80.8.595

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  27 in total

1.  Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.

Authors:  Gunisha Sagar; Raghuwansh P Sah; Naureen Javeed; Shamit K Dutta; Thomas C Smyrk; Julie S Lau; Nino Giorgadze; Tamar Tchkonia; James L Kirkland; Suresh T Chari; Debabrata Mukhopadhyay
Journal:  Gut       Date:  2015-04-28       Impact factor: 23.059

Review 2.  Cancer cachexia, mechanism and treatment.

Authors:  Tomoyoshi Aoyagi; Krista P Terracina; Ali Raza; Hisahiro Matsubara; Kazuaki Takabe
Journal:  World J Gastrointest Oncol       Date:  2015-04-15

Review 3.  Cytokines as mediators in the regulation of the hypothalamic-pituitary-adrenocortical function.

Authors:  J Fukata; H Imura; K Nakao
Journal:  J Endocrinol Invest       Date:  1994-02       Impact factor: 4.256

Review 4.  Cancer cachexia: its correlations and causes.

Authors:  Harry Rubin
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-17       Impact factor: 11.205

5.  Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients.

Authors:  M Maltoni; L Fabbri; O Nanni; E Scarpi; L Pezzi; E Flamini; A Riccobon; S Derni; G Pallotti; D Amadori
Journal:  Support Care Cancer       Date:  1997-03       Impact factor: 3.603

6.  Evidence for the involvement of interleukin 6 in experimental cancer cachexia.

Authors:  G Strassmann; M Fong; J S Kenney; C O Jacob
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

7.  Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.

Authors:  K J Tracey; S Morgello; B Koplin; T J Fahey; J Fox; A Aledo; K R Manogue; A Cerami
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

8.  Relationship between soluble tumor necrosis factor (TNF) receptors and TNF alpha during immunotherapy with interleukin-2 and/or interferon alpha.

Authors:  R Landmann; U Keilholz; C Scheibenbogen; M Brockhaus; H Gallati; H Denz; M Bargetzi; C Ludwig
Journal:  Cancer Immunol Immunother       Date:  1994-02       Impact factor: 6.968

Review 9.  Are cytokines possible mediators of cancer cachexia?

Authors:  Y Noguchi; T Yoshikawa; A Matsumoto; G Svaninger; J Gelin
Journal:  Surg Today       Date:  1996       Impact factor: 2.549

10.  The presence of tumor necrosis factor-alpha and its antibody in the sera of cachexic patients with gastrointestinal cancer.

Authors:  T Kiyama; M Onda; A Tokunaga; I Fujita; T Okuda; T Mizutani; N Matsukura; Y Todome; H Ohkuni
Journal:  Surg Today       Date:  1994       Impact factor: 2.549
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