Aims: To investigate the association of vitamin D deficiency with cardiovascular autonomic nervous system function in children and adolescents with vasovagal syncope (VVS). Methods: This study recruited 76 pediatric patients with VVS and 15 healthy children. The 25-hydroxyvitamin D levels in serum among the participants were evaluated. Heart rate variability analysis including SDNN, rMSSD, and SDANN was tested in patients with VVS. The correlation between indices of time-domain analysis and serum vitamin D status of the children with VVS was investigated. Results: In this work, 25-hydroxyvitamin D levels in serum among VVS cases remarkably decreased compared with those among healthy controls (48.76 ± 19.25 vs. 67.62 ± 15.46 nmol/L, p < 0.01). The vitamin D deficient patients with VVS exhibited a lower rMSDD value compared to the non-deficient group with VVS (45.56 ± 16.87 vs. 61.90 ± 20.38 ms, p < 0.001, respectively). Pearson correlation analysis indicated that serum 25-hydroxyvitamin D levels had positive correlation with rMSDD values (r = 0.466, p < 0.001). Conclusions: As suggested by our data, VVS children and adolescents with vitamin D deficiency may have cardiac autonomic dysfunction and cardiac vagal tone decreases with the reduction in vitamin D level.
Aims: To investigate the association of vitamin D deficiency with cardiovascular autonomic nervous system function in children and adolescents with vasovagal syncope (VVS). Methods: This study recruited 76 pediatric patients with VVS and 15 healthy children. The 25-hydroxyvitamin D levels in serum among the participants were evaluated. Heart rate variability analysis including SDNN, rMSSD, and SDANN was tested in patients with VVS. The correlation between indices of time-domain analysis and serum vitamin D status of the children with VVS was investigated. Results: In this work, 25-hydroxyvitamin D levels in serum among VVS cases remarkably decreased compared with those among healthy controls (48.76 ± 19.25 vs. 67.62 ± 15.46 nmol/L, p < 0.01). The vitamin D deficient patients with VVS exhibited a lower rMSDD value compared to the non-deficient group with VVS (45.56 ± 16.87 vs. 61.90 ± 20.38 ms, p < 0.001, respectively). Pearson correlation analysis indicated that serum 25-hydroxyvitamin D levels had positive correlation with rMSDD values (r = 0.466, p < 0.001). Conclusions: As suggested by our data, VVSchildren and adolescents with vitamin D deficiency may have cardiac autonomic dysfunction and cardiac vagal tone decreases with the reduction in vitamin D level.
Authors: Michael F Holick; Neil C Binkley; Heike A Bischoff-Ferrari; Catherine M Gordon; David A Hanley; Robert P Heaney; M Hassan Murad; Connie M Weaver Journal: J Clin Endocrinol Metab Date: 2011-06-06 Impact factor: 5.958
Authors: Karani S Vimaleswaran; Alana Cavadino; Diane J Berry; Rolf Jorde; Aida Karina Dieffenbach; Chen Lu; Alexessander Couto Alves; Hiddo J Lambers Heerspink; Emmi Tikkanen; Joel Eriksson; Andrew Wong; Massimo Mangino; Kathleen A Jablonski; Ilja M Nolte; Denise K Houston; Tarunveer Singh Ahluwalia; Peter J van der Most; Dorota Pasko; Lina Zgaga; Elisabeth Thiering; Veronique Vitart; Ross M Fraser; Jennifer E Huffman; Rudolf A de Boer; Ben Schöttker; Kai-Uwe Saum; Mark I McCarthy; Josée Dupuis; Karl-Heinz Herzig; Sylvain Sebert; Anneli Pouta; Jaana Laitinen; Marcus E Kleber; Gerjan Navis; Mattias Lorentzon; Karen Jameson; Nigel Arden; Jackie A Cooper; Jayshree Acharya; Rebecca Hardy; Olli Raitakari; Samuli Ripatti; Liana K Billings; Jari Lahti; Clive Osmond; Brenda W Penninx; Lars Rejnmark; Kurt K Lohman; Lavinia Paternoster; Ronald P Stolk; Dena G Hernandez; Liisa Byberg; Emil Hagström; Håkan Melhus; Erik Ingelsson; Dan Mellström; Osten Ljunggren; Ioanna Tzoulaki; Stela McLachlan; Evropi Theodoratou; Carla M T Tiesler; Antti Jula; Pau Navarro; Alan F Wright; Ozren Polasek; James F Wilson; Igor Rudan; Veikko Salomaa; Joachim Heinrich; Harry Campbell; Jacqueline F Price; Magnus Karlsson; Lars Lind; Karl Michaëlsson; Stefania Bandinelli; Timothy M Frayling; Catharina A Hartman; Thorkild I A Sørensen; Stephen B Kritchevsky; Bente Lomholt Langdahl; Johan G Eriksson; Jose C Florez; Tim D Spector; Terho Lehtimäki; Diana Kuh; Steve E Humphries; Cyrus Cooper; Claes Ohlsson; Winfried März; Martin H de Borst; Meena Kumari; Mika Kivimaki; Thomas J Wang; Chris Power; Hermann Brenner; Guri Grimnes; Pim van der Harst; Harold Snieder; Aroon D Hingorani; Stefan Pilz; John C Whittaker; Marjo-Riitta Järvelin; Elina Hyppönen Journal: Lancet Diabetes Endocrinol Date: 2014-06-25 Impact factor: 32.069