| Literature DB >> 3373221 |
Y H Choi1, J M Pezzuto, A D Kinghorn, N R Farnsworth.
Abstract
In addition to the previously characterized agrostistachin, three additional cytotoxic macrocyclic casbane-type diterpenes were isolated from a CHCl3 extract of Agrostistachys hookeri, by bioactivity-guided fractionation using the P-388 lymphocytic leukemia cell culture system. These novel compounds, 14-dehydroagrostistachin, 17-hydroxyagrostistachin, and agroskerin, identified by spectral data comparison to agrostistachin and demonstrated ED50 values of 2.8, 0.8, and 1.4 micrograms/ml, respectively, with cultured P-388 cells.Entities:
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Year: 1988 PMID： 3373221 DOI： 10.1021/np50055a016
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050