Background: Parkinson's disease (PD) and osteoporosis are both common aging diseases. It is reported that PD has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progression. Objectives: To detect the bone-derived factors in plasma and cerebrospinal fluid (CSF) of patients with PD and evaluate their correlations with C-reaction protein (CRP) level, motor impairment, and Hoehn-Yahr (HY) stage of the disease. Methods: We included 250 PD patients and 250 controls. Levels of osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), Sclerostin (SO), Bone morphogenetic protein 2 (BMP2), and Dickkopf-1 (DKK-1) in plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann-Whitney U-test and Spearman's receptor activator of NF-κB (RANK) correlation. Results: Plasma levels of OCN and OPN were correlated with CRP levels and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. Conclusions: OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talk between the two factors and PD.
Background: Parkinson's disease (PD) and osteoporosis are both common aging diseases. It is reported that PD has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progression. Objectives: To detect the bone-derived factors in plasma and cerebrospinal fluid (CSF) of patients with PD and evaluate their correlations with C-reaction protein (CRP) level, motor impairment, and Hoehn-Yahr (HY) stage of the disease. Methods: We included 250 PDpatients and 250 controls. Levels of osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), Sclerostin (SO), Bone morphogenetic protein 2 (BMP2), and Dickkopf-1 (DKK-1) in plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann-Whitney U-test and Spearman's receptor activator of NF-κB (RANK) correlation. Results: Plasma levels of OCN and OPN were correlated with CRP levels and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. Conclusions: OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talk between the two factors and PD.
Authors: Walter Maetzler; Daniela Berg; Natalie Schalamberidze; Arthur Melms; Klaus Schott; Jakob C Mueller; Lucy Liaw; Thomas Gasser; Cordula Nitsch Journal: Neurobiol Dis Date: 2006-12-26 Impact factor: 5.996
Authors: Joanna Iczkiewicz; Lauren Broom; Jonathan D Cooper; Andrew Ming Sham Wong; Sarah Rose; Peter Jenner Journal: J Neurochem Date: 2010-08-03 Impact factor: 5.372
Authors: Susan R Goulding; Aideen M Sullivan; Gerard W O'Keeffe; Louise M Collins Journal: Parkinsonism Relat Disord Date: 2019-04-11 Impact factor: 4.891
Authors: Alejandra Camacho-Soto; Anat Gross; Susan Searles Nielsen; Anna N Miller; Mark N Warden; Amber Salter; Brad A Racette Journal: Neurology Date: 2020-04-28 Impact factor: 9.910
Authors: Altan Rentsendorj; Julia Sheyn; Dieu-Trang Fuchs; David Daley; Brenda C Salumbides; Hannah E Schubloom; Nadav J Hart; Songlin Li; Eric Y Hayden; David B Teplow; Keith L Black; Yosef Koronyo; Maya Koronyo-Hamaoui Journal: Brain Behav Immun Date: 2017-08-30 Impact factor: 19.227
Authors: Steven Bradburn; Jamie S McPhee; Liam Bagley; Sarianna Sipila; Lauri Stenroth; Marco Vincenzo Narici; Mati Pääsuke; Helena Gapeyeva; Gabrielle Osborne; Lorraine Sassano; Carel G M Meskers; Andrea B Maier; Jean-Yves Hogrel; Yoann Barnouin; Gillian Butler-Browne; Chris Murgatroyd Journal: Age Ageing Date: 2016-08-11 Impact factor: 10.668