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Literature DB >> 3373171

A fatality involving U4Euh, a cyclic derivative of phenylpropanolamine.

F T Davis¹, M E Brewster.
1. Orlando Crime Laboratory, FL.

Abstract

A fatality following ingestion of diazepam and 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine, a cyclic derivative of phenylpropanolamine known as U4EuH or 4-methyl aminorex, is described. Solid dosage samples of U4EuH were analyzed using gas chromatography, ultraviolet and infrared spectroscopy, nuclear magnetic resonance, and mass spectrometry. Physiological fluids were analyzed quantitatively by gas chromatography and qualitatively by gas chromatography-mass spectrometry. Concentrations of 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine were: in blood 21.3 mg/L; in urine 12.3 mg/L. Diazepam concentration in blood was 0.8 mg/L.

Entities: Chemical

Mesh：

Substances：

Year: 1988 PMID： 3373171

Source DB: PubMed Journal: J Forensic Sci ISSN： 0022-1198 Impact factor: 1.832

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Cited

6 in total

1. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR).

Authors: Gavin McLaughlin; Noreen Morris; Pierce V Kavanagh; John D Power; Brendan Twamley; John O'Brien; Brian Talbot; Geraldine Dowling; Olivia Mahony; Simon D Brandt; Julian Patrick; Roland P Archer; John S Partilla; Michael H Baumann
Journal: Drug Test Anal Date: 2014-10-20 Impact factor: 3.345

2. Novel psychoactive substances of interest for psychiatry.

Authors: Fabrizio Schifano; Laura Orsolini; G Duccio Papanti; John M Corkery
Journal: World Psychiatry Date: 2015-02 Impact factor: 49.548

3. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni').

Authors: Simon D Brandt; Michael H Baumann; John S Partilla; Pierce V Kavanagh; John D Power; Brian Talbot; Brendan Twamley; Olivia Mahony; John O'Brien; Simon P Elliott; Roland P Archer; Julian Patrick; Kuldip Singh; Nicola M Dempster; Simon H Cosbey
Journal: Drug Test Anal Date: 2014-05-19 Impact factor: 3.345

A fatality involving U4Euh, a cyclic derivative of phenylpropanolamine.

1. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR).

2. Novel psychoactive substances of interest for psychiatry.

3. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni').

Review 4. DARK Classics in Chemical Neuroscience: Aminorex Analogues.

5. Characterization of a recently detected halogenated aminorex derivative: para-fluoro-4-methylaminorex (4'F-4-MAR).

Review 6. Designer drugs: mechanism of action and adverse effects.