Literature DB >> 33731690

Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition.

Ashiq Masood1,2, Trevor Christ3,4, Samia Asif5, Priya Rajakumar6, Beth A Gustafson7, Leyla O Shune8, Ameen Salahudeen9, Drew Nedvad10, Suparna Nanua11, Agne Paner6, Timothy M Kuzel6, Mia Levy6, Janakiraman Subramanian7,12, Shahzad Raza12.   

Abstract

Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.

Entities:  

Year:  2021        PMID： 33731690      PMCID： PMC7969947          DOI： 10.1038/s41525-021-00186-9

Source DB:  PubMed          Journal:  NPJ Genom Med        ISSN： 2056-7944            Impact factor:   8.617


  20 in total

1.  TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.

Authors:  L Hernández; M Pinyol; S Hernández; S Beà; K Pulford; A Rosenwald; L Lamant; B Falini; G Ott; D Y Mason; G Delsol; E Campo
Journal:  Blood       Date:  1999-11-01       Impact factor: 22.113

2.  ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript.

Authors:  Wei-ya Wang; Ling Gu; Wei-ping Liu; Gan-di Li; Hua-jun Liu; Zhi-gui Ma
Journal:  Pathol Res Pract       Date:  2011-08-19       Impact factor: 3.250

3.  Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides.

Authors:  Jan B Egan; Chang-Xin Shi; Waibhav Tembe; Alexis Christoforides; Ahmet Kurdoglu; Shripad Sinari; Sumit Middha; Yan Asmann; Jessica Schmidt; Esteban Braggio; Jonathan J Keats; Rafael Fonseca; P Leif Bergsagel; David W Craig; John D Carpten; A Keith Stewart
Journal:  Blood       Date:  2012-04-23       Impact factor: 22.113

4.  Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.

Authors:  J Zachary Sanborn; Jongsuk Chung; Elizabeth Purdom; Nicholas J Wang; Hojabr Kakavand; James S Wilmott; Timothy Butler; John F Thompson; Graham J Mann; Lauren E Haydu; Robyn P M Saw; Klaus J Busam; Roger S Lo; Eric A Collisson; Joe S Hur; Paul T Spellman; James E Cleaver; Joe W Gray; Nam Huh; Rajmohan Murali; Richard A Scolyer; Boris C Bastian; Raymond J Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-18       Impact factor: 11.205

5.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.

Authors:  Ben Langmead; Cole Trapnell; Mihai Pop; Steven L Salzberg
Journal:  Genome Biol       Date:  2009-03-04       Impact factor: 13.583

6.  Alectinib in RET-rearranged non-small cell lung cancer-Another progress in precision medicine?

Authors:  Robert Pirker; Martin Filipits
Journal:  Transl Lung Cancer Res       Date:  2015-12

7.  Review of 1027 patients with newly diagnosed multiple myeloma.

Authors:  Robert A Kyle; Morie A Gertz; Thomas E Witzig; John A Lust; Martha Q Lacy; Angela Dispenzieri; Rafael Fonseca; S Vincent Rajkumar; Janice R Offord; Dirk R Larson; Matthew E Plevak; Terry M Therneau; Philip R Greipp
Journal:  Mayo Clin Proc       Date:  2003-01       Impact factor: 7.616

Review 8.  Tyrosine kinase gene rearrangements in epithelial malignancies.

Authors:  Alice T Shaw; Peggy P Hsu; Mark M Awad; Jeffrey A Engelman
Journal:  Nat Rev Cancer       Date:  2013-10-17       Impact factor: 60.716

9.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.

Authors:  Bo Li; Colin N Dewey
Journal:  BMC Bioinformatics       Date:  2011-08-04       Impact factor: 3.307

10.  Fast and accurate short read alignment with Burrows-Wheeler transform.

Authors:  Heng Li; Richard Durbin
Journal:  Bioinformatics       Date:  2009-05-18       Impact factor: 6.937
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  1 in total

1.  Association of anaplastic lymphoma kinase variants and alterations with ensartinib response duration in non-small cell lung cancer.

Authors:  Donghui Hou; Xiaomin Zheng; Wei Song; Xiaoqing Liu; Sicong Wang; Lina Zhou; Xiuli Tao; Lv Lv; Qi Sun; Yujing Jin; Zewei Zhang; Lieming Ding; Ning Wu; Shijun Zhao
Journal:  Thorac Cancer       Date:  2021-07-20       Impact factor: 3.500
  1 in total

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