| Literature DB >> 33731424 |
Sarah B Windle1, Mark J Eisenberg1, Pauline Reynier1, Josselin Cabaussel1, Brett D Thombs1, Roland Grad1, Carolyn Ells1, Crystal Sequeira1, Kristian B Filion2.
Abstract
BACKGROUND: With the recent legalization of recreational cannabis in Canada, cannabis-impaired driving is an important public safety concern. Our aim was to examine the association between recreational cannabis legalization and fatal motor vehicle collisions using data from the United States, which present a timely natural experiment of cannabis legalization.Entities:
Year: 2021 PMID: 33731424 PMCID: PMC8096392 DOI: 10.9778/cmajo.20200155
Source DB: PubMed Journal: CMAJ Open ISSN: 2291-0026
United States jurisdictions with regulations for legalized recreational cannabis in effect before 2019
| Jurisdiction | Date legalization in effect | First month legalization in effect for primary analysis | Date commercial dispensaries open | First month commercial dispensaries open for sensitivity analysis | Cannabis-specific impaired driving law |
|---|---|---|---|---|---|
| Alaska | Feb. 24, 2015 | March 2015 | Oct. 29, 2016 | November 2016 | None |
| California | Nov. 9, 2016 | November 2016 | Jan. 1, 2018 | January 2018 | None |
| Colorado | Dec. 10, 2012 | December 2012 | Jan. 1, 2014 | January 2014 | Reasonable inference for impairment ≥ 5 ng/mL THC |
| District of Columbia | Feb. 26, 2015 | March 2015 | No commercial | NA | None |
| Maine | Jan. 30, 2017 | February 2017 | Oct. 9, 2020 | NA | None |
| Massachusetts | Dec. 15, 2016 | December 2016 | Nov. 20, 2018 | December 2018 | None |
| Michigan | Dec. 6, 2018 | December 2018 | Dec. 1, 2019 | NA | Zero tolerance (no detectable presence of cannabis permitted) |
| Nevada | Jan. 1, 2017 | January 2017 | July 1, 2017 | July 2017 | Per se limit ≥ 2 ng/mL THC |
| Oregon | July 1, 2015 | July 2015 | Oct. 1, 2015 | October 2015 | None |
| Vermont | July 1, 2018 | July 2018 | No commercial dispensaries | NA | None |
| Washington | Dec. 6, 2012 | December 2012 | July 8, 2014 | July 2014 | Per se limit ≥ 5 ng/mL THC |
Note: NA = no data available for legalized (or commercial dispensaries open) months before 2019, THC = tetrahydrocannabinol.
Rounded up or down to the nearest full month of legalization (or commercial dispensaries opening, for sensitivity analysis).
Reasonable inference requires that the jurisdiction must prove with other evidence, in addition to exceeding the legal THC limit, that the driver was impaired.
On Dec. 1, 2019, existing medical cannabis dispensaries in Michigan were permitted to transfer up to 50% of their medical cannabis inventory to recreational cannabis inventory. Until November 2021, retailers must hold a medical cannabis licence in order to apply for a recreational cannabis licence.
Per se limits do not require that the jurisdiction prove that drivers were impaired in order to charge them with driving under the influence if their THC level exceeded the legal limit.
On Oct. 1, 2015, existing medical cannabis dispensaries in Oregon were permitted to sell recreational cannabis. The first licences were issued to recreational cannabis retailers on Oct. 1, 2016.
Fatal motor vehicle collisions and associated deaths from 2007 to 2018 in United States jurisdictions with legalized recreational cannabis
| Event | No. of events | Person-years of observation | Rate per 100 000 person-years (95% CI) | IRR (95% CI) | |
|---|---|---|---|---|---|
| Crude | Adjusted | ||||
| Fatal motor vehicle collision | 73 982 | 924 545 813 | 8.00 (7.94–8.06) | ||
| No legalization | 56 866 | 717 561 813.4 | 7.92 (7.86–7.99) | 1.00 (reference) | 1.00 (reference) |
| Legalization | 17 116 | 206 983 999.6 | 8.27 (8.15–8.39) | 1.05 (0.99–1.12) | 1.15 (1.06–1.26) |
| Death from motor vehicle collision | 80 402 | 924 545 813 | 8.70 (8.64–8.76) | ||
| No legalization | 61 822 | 717 561 813.4 | 8.62 (8.55–8.68) | 1.00 (reference) | 1.00 (reference) |
| Legalization | 18 580 | 206 983 999.6 | 8.98 (8.85–9.11) | 1.04 (0.98–1.11) | 1.16 (1.06–1.27) |
| Fatal motor vehicle collision | 60 518 | 774 128 598 | 7.82 (7.76–7.88) | ||
| No open dispensaries | 50 275 | 653 841 729.2 | 7.69 (7.62–7.76) | 1.00 (reference) | 1.00 (reference) |
| Open dispensaries | 10 243 | 120 286 868.8 | 8.52 (8.35–8.68) | 1.08 (1.03–1.14) | 1.18 (1.06–1.32) |
| Death from motor vehicle collision | 65 835 | 774 128 598 | 8.50 (8.44–8.57) | ||
| No open dispensaries | 54 685 | 653 841 729.2 | 8.36 (8.29–8.43) | 1.00 (reference) | 1.00 (reference) |
| Open dispensaries | 11 150 | 120 286 868.8 | 9.27 (9.10–9.44) | 1.08 (1.03–1.14) | 1.18 (1.06–1.32) |
Note: CI = confidence interval, IRR = incidence rate ratio.
Adjusted for calendar year, modelled as a continuous variable.
See Appendix 1, Supplemental Tables S1–S4 (available at www.cmajopen.ca/content/9/1/E233/suppl/DC1) for jurisdiction-specific event rates.
The variance inflation factor for calendar year and legalization status ranged from 1.02 in Michigan to 4.03 in Colorado and Washington (Appendix 1, Supplemental Table S5).
The variance inflation factor for calendar year and open dispensary status ranged from 1.02 in Michigan to 3.76 in Colorado (Appendix 1, Supplemental Table S5).
Figure 1:Forest plot of fatal motor vehicle collisions (A) and associated deaths (B) from 2007 to 2018 in United States jurisdictions with legalized recreational cannabis. *Adjusted for calendar year, modelled as a continuous variable. Note: CI = confidence interval, IRR = incidence rate ratio.
Figure 2:Forest plot of fatal motor vehicle collisions (A) and associated deaths (B) from 2007 to 2018 in United States jurisdictions with open recreational cannabis dispensaries. *Adjusted for calendar year, modelled as a continuous variable. Note: CI = confidence interval, IRR = incidence rate ratio.
Fatal motor vehicle collisions and associated deaths from 2007 to 2018 in United States jurisdictions with legalized recreational cannabis, comparing the first 12 months to subsequent months
| Event | No. of events | Person-years of observation | Rate per 100 000 person-years (95% CI) | IRR (95% CI) | |
|---|---|---|---|---|---|
| Crude | Adjusted | ||||
| Fatal motor vehicle collision | 73 982 | 924 545 813 | 8.00 (7.94–8.06) | ||
| No legalization | 68 180 | 855 020 030.8 | 7.92 (7.86–7.99) | 1.00 (reference) | 1.00 (reference) |
| First 12 mo after legalization | 5802 | 69 525 782.3 | 8.35 (8.13–8.56) | 1.01 (0.93–1.11) | 1.12 (1.01–1.23) |
| Subsequent months after legalization | 11 314 | 137 458 217.3 | 8.23 (8.08–8.38) | 1.06 (1.00–1.13) | 1.22 (1.11–1.35) |
| First 12 mo v. subsequent months | – | – | – | 0.96 (0.88–1.05) | 0.92 (0.84–1.02) |
| Death from motor vehicle collision | 80 402 | 924 545 813 | 8.70 (8.64–8.76) | – | |
| No legalization | 61 822 | 717 561 813.4 | 8.62 (8.55–8.68) | 1.00 (reference) | 1.00 (reference) |
| First 12 mo after legalization | 6290 | 69 525 782.3 | 9.05 (8.83–9.27) | 1.00 (0.92–1.10) | 1.11 (1.00–1.24) |
| Subsequent months after legalization | 12 290 | 137 458 217.3 | 8.94 (8.78–9.10) | 1.06 (1.00–1.12) | 1.23 (1.11–1.37) |
| First 12 mo v. subsequent months | – | – | – | 0.96 (0.89–1.04) | 0.92 (0.84–1.01) |
| Fatal motor vehicle collision | 60 518 | 774 128 598 | 7.82 (7.76–7.88) | ||
| No open dispensaries | 50 275 | 653 841 729.2 | 7.69 (7.62–7.76) | 1.00 (reference) | 1.00 (reference) |
| First 12 mo of open dispensaries | 4968 | 60 437 733.9 | 8.22 (7.99–8.45) | 1.03 (0.95–1.13) | 1.13 (1.03–1.24) |
| Subsequent months of open dispensaries | 5275 | 59 849 134.9 | 8.81 (8.58–9.05) | 1.13 (1.08–1.18) | 1.34 (1.24–1.46) |
| First 12 mo v. subsequent months | – | – | – | 0.92 (0.82–1.04) | 0.88 (0.76–1.02) |
| Death from motor vehicle collision | 65 835 | 774 128 598 | 8.50 (8.44–8.57) | ||
| No open dispensaries | 54 685 | 653 841 729.2 | 8.36 (8.29–8.43) | 1.00 (reference) | 1.00 (reference) |
| First 12 mo of open dispensaries | 5426 | 60 437 733.9 | 8.98 (8.74–9.22) | 1.03 (0.95–1.13) | 1.13 (1.03–1.25) |
| Subsequent months of open dispensaries | 5724 | 59 849 134.9 | 9.56 (9.32–9.82) | 1.12 (1.07–1.17) | 1.35 (1.25–1.45) |
| First 12 mo v. subsequent months | – | – | – | 0.92 (0.82–1.03) | 0.88 (0.76–1.01) |
Note: CI = confidence interval, IRR = incidence rate ratio.
Adjusted for calendar year, modelled as a continuous variable.
Includes up to 12 months for each jurisdiction (some jurisdictions contributed less than 12 mo, depending on their dates of legalization or opening of dispensaries).
Excludes Michigan and Vermont (no subsequent months of legalization available).
Excludes California and Massachusetts (no subsequent months of open dispensaries available).