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Literature DB >> 33731188

Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology.

Francesca Di Modugno¹, Paola Nisticò², Sheila Spada³, Annalisa Tocci⁴.

Abstract

Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer. Among the ECM components, fibronectin and its fibrillary assembly represent the scaffold to build up the entire ECM structure, deeply affecting its features. Herein we focus on this extraordinary protein starting from its complex structure and defining its role in cancer as prognostic and theranostic marker.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Actin cytoskeleton; Cancer; Cancer-associated fibroblasts; Dormant cells; Extracellular matrix; Extracellular vesicles; Fibrillogenesis; Fibronectin; Metastasis; Metastatic niche

Year: 2021 PMID： 33731188 PMCID： PMC7972229 DOI： 10.1186/s13046-021-01908-8

Source DB: PubMed Journal: J Exp Clin Cancer Res ISSN： 0392-9078

199 in total

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Authors: Marko Hyytiäinen; Carita Penttinen; Jorma Keski-Oja
Journal: Crit Rev Clin Lab Sci Date: 2004 Impact factor: 6.250

2. Fibrillin assembly requires fibronectin.

Authors: Laetitia Sabatier; Daliang Chen; Christine Fagotto-Kaufmann; Dirk Hubmacher; Marc D McKee; Douglas S Annis; Deane F Mosher; Dieter P Reinhardt
Journal: Mol Biol Cell Date: 2008-11-26 Impact factor: 4.138

Review 3. The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.

Authors: Jonathon M Muncie; Valerie M Weaver
Journal: Curr Top Dev Biol Date: 2018-03-21 Impact factor: 4.897

Review 4. Shedding light on the cell biology of extracellular vesicles.

Authors: Guillaume van Niel; Gisela D'Angelo; Graça Raposo
Journal: Nat Rev Mol Cell Biol Date: 2018-01-17 Impact factor: 94.444

5. Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.

Authors: Taixue An; Sihua Qin; Dehua Sun; Yiyao Huang; Yanwei Hu; Shaopeng Li; Han Zhang; Bo Li; Bo Situ; Linmiao Lie; Yingsong Wu; Lei Zheng
Journal: Proteomics Date: 2019-05-27 Impact factor: 3.984

6. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer.

Authors: Monica Santimaria; Giovanni Moscatelli; Giuseppe L Viale; Leonardo Giovannoni; Giovanni Neri; Francesca Viti; Alessandra Leprini; Laura Borsi; Patrizia Castellani; Luciano Zardi; Dario Neri; Pietro Riva
Journal: Clin Cancer Res Date: 2003-02 Impact factor: 12.531

7. Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Authors: Kandice R Levental; Hongmei Yu; Laura Kass; Johnathon N Lakins; Mikala Egeblad; Janine T Erler; Sheri F T Fong; Katalin Csiszar; Amato Giaccia; Wolfgang Weninger; Mitsuo Yamauchi; David L Gasser; Valerie M Weaver
Journal: Cell Date: 2009-11-25 Impact factor: 41.582

8. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression.

Authors: Shouwei Han; Neil Sidell; Susanne Roser-Page; Jesse Roman
Journal: Int J Cancer Date: 2004-09-01 Impact factor: 7.396

9. FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.

Authors: Swati Bhattacharyya; Zenshiro Tamaki; Wenxia Wang; Monique Hinchcliff; Paul Hoover; Spiro Getsios; Eric S White; John Varga
Journal: Sci Transl Med Date: 2014-04-16 Impact factor: 17.956

10. Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination.

Authors: Marco Montagner; Rahul Bhome; Steven Hooper; Probir Chakravarty; Xiao Qin; Jahangir Sufi; Ajay Bhargava; Colin D H Ratcliffe; Yutaka Naito; Arianna Pocaterra; Christopher J Tape; Erik Sahai
Journal: Nat Cell Biol Date: 2020-02-24 Impact factor: 28.824

13 in total

1. Dysadherin awakens mechanical forces and promotes colorectal cancer progression.

Authors: So-Yeon Park; Choong-Jae Lee; Jang-Hyun Choi; Jee-Heun Kim; Won-Jae Lee; Tae-Young Jang; So-El Jeon; Jae-Hyun Kim; Sang-Hee Cho; Ji-Shin Lee; Jeong-Seok Nam
Journal: Theranostics Date: 2022-05-21 Impact factor: 11.600

2. Treatment of Acute Wounds With Recombinant Human-Like Collagen and Recombinant Human-Like Fibronectin in C57BL/6 Mice Individually or in Combination.

Authors: Yunqing Dong; Weidong Zhu; Xiaoxuan Lei; Xin Luo; Qi Xiang; Xuanru Zhu; Qiao Pan; Panshi Jin; Biao Cheng
Journal: Front Bioeng Biotechnol Date: 2022-05-19

Review 3. The RAGE/multiligand axis: a new actor in tumor biology.

Authors: Armando Rojas; Ivan Schneider; Cristian Lindner; Ileana Gonzalez; Miguel A Morales
Journal: Biosci Rep Date: 2022-07-29 Impact factor: 3.976

Review 4. Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer.

Authors: Armando Rojas; Cristian Lindner; Iván Schneider; Ileana Gonzàlez; Hernan Araya; Erik Morales; Milibeth Gómez; Nelson Urdaneta; Paulina Araya; Miguel Angel Morales
Journal: World J Gastrointest Oncol Date: 2021-12-15

Review 5. The Functional Role of Extracellular Matrix Proteins in Cancer.

Authors: Nadezhda V Popova; Manfred Jücker
Journal: Cancers (Basel) Date: 2022-01-04 Impact factor: 6.639

6. Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.

Authors: Paola Spessotto; Maurizio Mongiat; Eva Andreuzzi; Albina Fejza; Maurizio Polano; Evelina Poletto; Lucrezia Camicia; Greta Carobolante; Giulia Tarticchio; Federico Todaro; Emma Di Carlo; Melania Scarpa; Marco Scarpa; Alice Paulitti; Alessandra Capuano; Vincenzo Canzonieri; Stefania Maiero; Mara Fornasarig; Renato Cannizzaro; Roberto Doliana; Alfonso Colombatti
Journal: J Exp Clin Cancer Res Date: 2022-02-11

7. Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes.

Authors: Qi Yang; Hongman Zhang; Ting Wei; Anqi Lin; Yueqin Sun; Peng Luo; Jian Zhang
Journal: Front Immunol Date: 2021-11-05 Impact factor: 7.561