Hyo-Geun Choi1,2,3, Soo-Hwan Byun4,5, Seok-Jin Hong6,7, Byoung-Eun Yang6,8, Dae-Myoung Yoo9, Sung-Jae Kim10. 1. Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon, 24252, Korea. pupen@naver.com. 2. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. pupen@naver.com. 3. Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, 14068, Korea. pupen@naver.com. 4. Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon, 24252, Korea. purheit@daum.net. 5. Department of Oral and Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Anyang, 14068, Korea. purheit@daum.net. 6. Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon, 24252, Korea. 7. Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan, 18450, Korea. 8. Department of Oral and Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Anyang, 14068, Korea. 9. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. 10. Department of Orthopaedic Surgery, Hallym University College of Medicine, Dongtan, 18450, Korea.
Abstract
BACKGROUND: Chronic periodontitis is a multifactorial inflammatory disease resulting in patients exhibiting high levels of inflammatory factors causing systemic inflammatory bone destruction that may lead to osteoporosis development. The association between periodontitis and osteoporosis has been documented; however, the findings remain unclear. This study aimed to identify the association between periodontitis and osteoporosis using a cross-sectional study design and Korean Genome and Epidemiology Study (KoGES) health examinee data. METHODS: This cross-sectional study used epidemiological data from the KoGES during 2004-2016. Of 125,324 participants (age, 40-79 years), 9969 with periodontitis and 115,332 controls (without periodontitis) were selected. We analyzed the history of osteoporosis and fractures of all participants. All participants were examined according to age, sex, income group, obesity, smoking habits, alcohol consumption, and food intake. To analyze the odds ratio (OR) of periodontitis for those with osteoporosis and fractures, a logistic regression model was used. RESULTS: The adjusted odds ratio (aOR) of periodontitis for osteoporosis was 2.16 (95% confidence interval [CI], 2.01-2.31; P < 0.001). The aOR of periodontitis for any fracture was 1.54 (95% CI 1.46-1.62; P < 0.001). CONCLUSION: Osteoporosis and fractures are associated with periodontitis. Performing regular oral hygiene and examinations of bone mineral density are recommended to prevent aggravation of osteoporosis and periodontitis.
BACKGROUND:Chronic periodontitis is a multifactorial inflammatory disease resulting in patients exhibiting high levels of inflammatory factors causing systemic inflammatory bone destruction that may lead to osteoporosis development. The association between periodontitis and osteoporosis has been documented; however, the findings remain unclear. This study aimed to identify the association between periodontitis and osteoporosis using a cross-sectional study design and Korean Genome and Epidemiology Study (KoGES) health examinee data. METHODS: This cross-sectional study used epidemiological data from the KoGES during 2004-2016. Of 125,324 participants (age, 40-79 years), 9969 with periodontitis and 115,332 controls (without periodontitis) were selected. We analyzed the history of osteoporosis and fractures of all participants. All participants were examined according to age, sex, income group, obesity, smoking habits, alcohol consumption, and food intake. To analyze the odds ratio (OR) of periodontitis for those with osteoporosis and fractures, a logistic regression model was used. RESULTS: The adjusted odds ratio (aOR) of periodontitis for osteoporosis was 2.16 (95% confidence interval [CI], 2.01-2.31; P < 0.001). The aOR of periodontitis for any fracture was 1.54 (95% CI 1.46-1.62; P < 0.001). CONCLUSION: Osteoporosis and fractures are associated with periodontitis. Performing regular oral hygiene and examinations of bone mineral density are recommended to prevent aggravation of osteoporosis and periodontitis.
Authors: B J Paster; S K Boches; J L Galvin; R E Ericson; C N Lau; V A Levanos; A Sahasrabudhe; F E Dewhirst Journal: J Bacteriol Date: 2001-06 Impact factor: 3.490
Authors: Jeneen Panezai; Ambereen Ghaffar; Mohammad Altamash; Mikael Åberg; Thomas E Van Dyke; Anders Larsson; Per-Erik Engström Journal: Biomedicines Date: 2022-03-19