Ruiling Xu1, Tara Alicia Pauley1, Hannah Missfelder-Lobos1, Richard John Haddon2, Ravindra Kumar Gupta3, Hsu Phern Chong4. 1. Department of Obstetrics & Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 0SQ, UK. 2. Department of Anaesthesia, Cambridge University NHS Hospitals Foundation Trust, Cambridge, CB2 0QQ, UK. 3. Department of Medicine, University of Cambridge, Cambridge, CB2 0AW, UK. 4. Department of Obstetrics & Gynaecology, Rosie Maternity Hospital, Cambridge, CB2 0SQ, UK. hsu.chong@nhs.net.
Abstract
BACKGROUND: Asymptomatic carriage of COVID-19 in pregnant women has been reported and could lead to outbreaks in maternity units. We sought to ascertain the impact of rapid isothernal nucleic acid based testing for COVID-19 in an unselected cohort of pregnant women attending our maternity unit. We also assessed the correlation between community prevalence and asymptomatic carriage. METHODS: Data for the retrospective cohort study were collected from a large UK tertiary maternity unit over a 4-week period using computerised hospital records. Literature searches were performed across multiple repositories. COVID-19 prevalence was extracted from online repositories. RESULTS: Nasopharyngeal and oropharyngeal swabs were obtained from 457/465 (98%) women during the study period. The median turnaround time for results was 5.3 h (interquartile range (IQR) 2.6-8.9 h), with 92% of the results returned within 24 h. In our cohort, only one woman tested positive, giving a screen positive rate of 0.22% (1/457; 95% CI: 0.04-1.23%). One woman who tested negative developed a fever postnatally following discharge but was lost to follow-up. From our literature review, we did not find any correlation between asymptomatic carriage in pregnant women and the reported regional prevalence of COVID-19. CONCLUSIONS: Testing using the SAMBA-II machine was acceptable to the vast majority of pregnant women requiring admission and had a low turnaround time. Asymptomatic carriage is low, but not correlated to community prevalence rates. Screening pregnant women on admission will remain an important component in order to minimise nosocomial infection.
BACKGROUND: Asymptomatic carriage of COVID-19 in pregnant women has been reported and could lead to outbreaks in maternity units. We sought to ascertain the impact of rapid isothernal nucleic acid based testing for COVID-19 in an unselected cohort of pregnant women attending our maternity unit. We also assessed the correlation between community prevalence and asymptomatic carriage. METHODS: Data for the retrospective cohort study were collected from a large UK tertiary maternity unit over a 4-week period using computerised hospital records. Literature searches were performed across multiple repositories. COVID-19 prevalence was extracted from online repositories. RESULTS: Nasopharyngeal and oropharyngeal swabs were obtained from 457/465 (98%) women during the study period. The median turnaround time for results was 5.3 h (interquartile range (IQR) 2.6-8.9 h), with 92% of the results returned within 24 h. In our cohort, only one woman tested positive, giving a screen positive rate of 0.22% (1/457; 95% CI: 0.04-1.23%). One woman who tested negative developed a fever postnatally following discharge but was lost to follow-up. From our literature review, we did not find any correlation between asymptomatic carriage in pregnant women and the reported regional prevalence of COVID-19. CONCLUSIONS: Testing using the SAMBA-II machine was acceptable to the vast majority of pregnant women requiring admission and had a low turnaround time. Asymptomatic carriage is low, but not correlated to community prevalence rates. Screening pregnant women on admission will remain an important component in order to minimise nosocomial infection.
Authors: D Ceulemans; I Thijs; A Schreurs; J Vercammen; L Lannoo; J Deprest; J Richter; L De Catte; R Devlieger Journal: Ultrasound Obstet Gynecol Date: 2020-07 Impact factor: 7.299
Authors: Petra Mlcochova; Dami Collier; Allyson Ritchie; Sonny M Assennato; Myra Hosmillo; Neha Goel; Bo Meng; Krishna Chatterjee; Vivien Mendoza; Nigel Temperton; Leo Kiss; Leo C James; Katarzyna A Ciazynska; Xiaoli Xiong; John A G Briggs; James A Nathan; Federica Mescia; Laura Bergamaschi; Hongyi Zhang; Petros Barmpounakis; Nikos Demeris; Richard Skells; Paul A Lyons; John Bradley; Steven Baker; Jean Pierre Allain; Kenneth G C Smith; Rachel Bousfield; Michael Wilson; Dominic Sparkes; Glenn Amoroso; Effrosyni Gkrania-Klotsas; Susie Hardwick; Adrian Boyle; Ian Goodfellow; Ravindra K Gupta Journal: Cell Rep Med Date: 2020-09-01
Authors: William S Vintzileos; Jolene Muscat; Eva Hoffmann; Nicole S John; Rosanne Vertichio; Anthony M Vintzileos; Duc Vo Journal: Am J Obstet Gynecol Date: 2020-04-26 Impact factor: 8.661
Authors: Michael J Fassett; Lawrence D Lurvey; Lyn Yasumura; Marielle Nguyen; Joseph J Colli; Marianna Volodarskiy; Jonathan C Gullett; David Braun; Alex Fong; Neha Trivedi; Katia Bruxvoort; Vicki Chiu; Darios Getahun Journal: Am J Perinatol Date: 2020-07-03 Impact factor: 1.862
Authors: Lucy Rivett; Sushmita Sridhar; Dominic Sparkes; Matthew Routledge; Nick K Jones; Ian G Goodfellow; Stephen Baker; Michael P Weekes; Sally Forrest; Jamie Young; Joana Pereira-Dias; William L Hamilton; Mark Ferris; M Estee Torok; Luke Meredith; Martin D Curran; Stewart Fuller; Afzal Chaudhry; Ashley Shaw; Richard J Samworth; John R Bradley; Gordon Dougan; Kenneth Gc Smith; Paul J Lehner; Nicholas J Matheson; Giles Wright Journal: Elife Date: 2020-05-11 Impact factor: 8.140
Authors: Sonny M Assennato; Allyson V Ritchie; Martin D Curran; Helen H Lee; Cesar Nadala; Neha Goel; Cuijuan Tie; Lourdes M Nadala; Hongyi Zhang; Rawlings Datir; Ravindra K Gupta Journal: J Clin Microbiol Date: 2020-12-17 Impact factor: 5.948
Authors: Alexander Hein; Sven Kehl; Lothar Häberle; Carsten Tiemann; Rebecca Peuker; Denise Mereutanu; Florian M Stumpfe; Florian Faschingbauer; Kirstin Meyer-Schlinkmann; Martin C Koch; Franz Kainer; Ulf Dammer; Hanna Philipp; Carolin Kladt; Michael G Schrauder; Stefan Weingärtler; Volker Hanf; Arndt Hartmann; Matthias Rübner; Holm Schneider; Jos Lelieveld; Matthias W Beckmann; Lena A Wurmthaler; Peter A Fasching; Michael O Schneider Journal: Geburtshilfe Frauenheilkd Date: 2022-02-11 Impact factor: 2.915