Literature DB >> 33728991

Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease.

Lu Xu1, Jingyang Zhou2, Jinhui Che1, Haihong Wang1, Weizhong Yang1, Wuyuan Zhou3, Hongying Zhao4.   

Abstract

Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.

Entities:  

Keywords:  AIM2; inflammasome; mitochondrial DNA; nonalcoholic fatty liver disease; oxidative stress

Mesh：

Substances：

Year:  2021        PMID： 33728991     DOI： 10.1152/ajpgi.00431.2020

Source DB:  PubMed          Journal:  Am J Physiol Gastrointest Liver Physiol        ISSN： 0193-1857            Impact factor:   4.052


  7 in total

1.  The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage.

Authors:  Chiara Rossi; Antonio Salvati; Mariarosaria Distaso; Daniela Campani; Francesco Raggi; Edoardo Biancalana; Domenico Tricò; Maurizia Rossana Brunetto; Anna Solini
Journal:  Int J Mol Sci       Date:  2022-07-04       Impact factor: 6.208

Review 2.  Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis.

Authors:  Can Gan; Qiuyu Cai; Chengwei Tang; Jinhang Gao
Journal:  Front Immunol       Date:  2022-05-30       Impact factor: 8.786

3.  Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation.

Authors:  Ying Wang; Chaojie Chen; Jiajun Chen; Tingting Sang; He Peng; Xiaojian Lin; Qian Zhao; Shengjia Chen; Thomas Eling; Xingya Wang
Journal:  Redox Biol       Date:  2022-04-27       Impact factor: 10.787

Review 4.  Mitochondrial control of inflammation.

Authors:  Saverio Marchi; Emma Guilbaud; Stephen W G Tait; Takahiro Yamazaki; Lorenzo Galluzzi
Journal:  Nat Rev Immunol       Date:  2022-07-25       Impact factor: 108.555

Review 5.  A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease.

Authors:  Chongbin Liu; Ming Yang; Li Li; Shilu Luo; Jinfei Yang; Chenrui Li; Huafeng Liu; Lin Sun
Journal:  Front Physiol       Date:  2022-07-06       Impact factor: 4.755

Review 6.  Roles of mitochondrial DNA in dynamics of the immune response to COVID-19.

Authors:  Ata Mahmoodpoor; Sarvin Sanaie; Zoherh Ostadi; Maqsoud Eskandari; Nazila Behrouzi; Roqayyeh Asghari; Ahmad Zahirnia; Nasim Sohrabifar; Somayeh Kazeminasab
Journal:  Gene       Date:  2022-06-18       Impact factor: 3.913

7.  Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.

Authors:  JiangFan Yu; Rui Tang; JinYu Li
Journal:  Front Oncol       Date:  2022-09-29       Impact factor: 5.738
  7 in total

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