Simone Oerlemans1, Sanne B Schagen2,3, Corina J van den Hurk4, Olga Husson2,5, Dounya Schoormans6, Lonneke V van de Poll-Franse4,2,6. 1. Department of Research and Development, Netherlands Comprehensive Cancer Organisation, P.O. Box 19079, 3501, DB, Utrecht, The Netherlands. s.oerlemans@iknl.nl. 2. Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands. 3. Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands. 4. Department of Research and Development, Netherlands Comprehensive Cancer Organisation, P.O. Box 19079, 3501, DB, Utrecht, The Netherlands. 5. Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. 6. CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
Abstract
PURPOSE: The aim was to investigate the level of self-perceived cognitive functioning and its associated factors among a large population-based cohort of cancer survivors and their matched controls. METHODS: Data were obtained from population-based PROFILES registry cohorts, including colon, rectum, prostate or thyroid cancer, Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia, multiple myeloma (MM), melanoma, or basal cell carcinoma (BCC)/squamous cell carcinoma (SCC). All patients completed the EORTC QLQ-C30 from which self-perceived cognitive functioning, fatigue, functioning, and global health status/quality of life (GHS/QoL) were used. The PROFILES registry data were linked with the Netherlands Cancer Registry to obtain sociodemographic and clinical data. RESULTS: Six thousand seven hundred eighty-six survivors were included (response rate=76%). Survivors, except for melanoma and BCC/SCC, reported on average lower self-perceived cognitive functioning scores compared to their matched controls (all p's<0.01). Largest differences with the norm were observed in thyroid cancer, HL, NHL and MM, and younger survivors (<50 years). Survivors with lower emotional functioning and more fatigue were more likely to report impaired self-perceived cognitive functioning. CONCLUSION: Self-perceived impaired cognitive functioning is prevalent among a wide range of cancer survivors, especially among survivors <50 years. Approaches targeting cognitive problems including attention for co-occurring symptoms such as fatigue and emotional impairments are needed to improve care for these patients. IMPLICATIONS FOR CANCER SURVIVORS: Cancer survivors and clinicians should be aware that impaired self-perceived cognitive functioning is a frequently reported consequence of cancer and its treatment among survivors of various cancer types. Clinicians can redirect survivors to a relevant healthcare provider or program to target cognitive problems.
PURPOSE: The aim was to investigate the level of self-perceived cognitive functioning and its associated factors among a large population-based cohort of cancer survivors and their matched controls. METHODS: Data were obtained from population-based PROFILES registry cohorts, including colon, rectum, prostate or thyroid cancer, Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia, multiple myeloma (MM), melanoma, or basal cell carcinoma (BCC)/squamous cell carcinoma (SCC). All patients completed the EORTC QLQ-C30 from which self-perceived cognitive functioning, fatigue, functioning, and global health status/quality of life (GHS/QoL) were used. The PROFILES registry data were linked with the Netherlands Cancer Registry to obtain sociodemographic and clinical data. RESULTS: Six thousand seven hundred eighty-six survivors were included (response rate=76%). Survivors, except for melanoma and BCC/SCC, reported on average lower self-perceived cognitive functioning scores compared to their matched controls (all p's<0.01). Largest differences with the norm were observed in thyroid cancer, HL, NHL and MM, and younger survivors (<50 years). Survivors with lower emotional functioning and more fatigue were more likely to report impaired self-perceived cognitive functioning. CONCLUSION: Self-perceived impaired cognitive functioning is prevalent among a wide range of cancer survivors, especially among survivors <50 years. Approaches targeting cognitive problems including attention for co-occurring symptoms such as fatigue and emotional impairments are needed to improve care for these patients. IMPLICATIONS FOR CANCER SURVIVORS: Cancer survivors and clinicians should be aware that impaired self-perceived cognitive functioning is a frequently reported consequence of cancer and its treatment among survivors of various cancer types. Clinicians can redirect survivors to a relevant healthcare provider or program to target cognitive problems.
Authors: Lonneke V van de Poll-Franse; Nicole Horevoorts; Dounya Schoormans; Sandra Beijer; Nicole P M Ezendam; Olga Husson; Simone Oerlemans; Sanne B Schagen; Geja J Hageman; Katrijn Van Deun; Corina van den Hurk; Mies van Eenbergen; Floortje Mols Journal: J Natl Cancer Inst Date: 2022-06-13 Impact factor: 11.816
Authors: Marloes van Gorp; Loes M E van Erp; Anne Maas; Leontien C M Kremer; Eline van Dulmen-den Broeder; Wim J E Tissing; Jacqueline J Loonen; Helena J H van der Pal; Andrica C H de Vries; Marry M van den Heuvel-Eibrink; Cécile M Ronckers; Dorine Bresters; Marloes Louwerens; Margriet van der Heiden-van der Loo; Gea A Huizinga; Heleen Maurice-Stam; Martha A Grootenhuis Journal: Cancer Date: 2021-11-02 Impact factor: 6.921