Lobna Bouzidi1, Hana Triki2, Slim Charfi3, Wala Ben Kridis4, Mohamed Derbel5, Lobna Ayadi3, Tahya Sellami-Boudawara3, Boutheina Cherif2. 1. Department of Pathology and Research Laboratory LR18SP10, University Hospital Habib Bourguiba, Sfax, Tunisia; Medical School of Sfax, University of Sfax, Sfax, Tunisia. Electronic address: lobnalobna1992@gmail.com. 2. Laboratory of Molecular and Cellular Screening Processes LR15CBS07, Centre de Biotechnologie de Sfax, University of Sfax, Sfax, Tunisia. 3. Department of Pathology and Research Laboratory LR18SP10, University Hospital Habib Bourguiba, Sfax, Tunisia; Medical School of Sfax, University of Sfax, Sfax, Tunisia. 4. Medical School of Sfax, University of Sfax, Sfax, Tunisia; Department of Medical Oncology, University Hospital Habib Bourguiba, Sfax, Tunisia. 5. Medical School of Sfax, University of Sfax, Sfax, Tunisia; Department of Gynecology and Obstetrics, University Hospital Hedi Chaker, Sfax, Tunisia.
Abstract
BACKGROUND: Each subgroup of immune cells has a different prognostic role in breast cancer; however, the prognostic impact of tumor-infiltrating natural killer cells (TINKs) is still not well established. Our aim was to assess the prognostic impact of natural killer (NK) cells in breast carcinomas. MATERIALS AND METHODS: NK cells infiltration were assessed by immunohistochemistry (IHC). Statistical analyses were performed to evaluate the correlation of NK cells with clinical-pathological features and outcome. RESULTS: CD56 IHC was realized in 126 patients. NK cells infiltration showed significant and positive association with tumor high Scarff-Bloom-Richardson (SBR) grade. NK cells were significantly associated with HER2-positive breast cancer and triple-negative breast cancer subtypes. Analyses showed significant and inverse correlation with progesterone and estrogen receptors expression status. High NK cells were significantly related to high Ki-67 labeling index. Our data showed that high NK cells infiltrate was significantly associated with tumor-infiltrating lymphocytes in breast cancer tissues. At a median follow-up of 5.5 years, high CD56 expression (≥ 5 cells/10 high power field) was associated significantly with a good overall survival and with good disease-free survival. CONCLUSION: In this study, we assessed the important prognostic role of TINKs in breast carcinomas, which seems to be evident despite its association with aggressive pathological features. Thus evaluation of NK cells can be standardized and integrated in daily routine.
BACKGROUND: Each subgroup of immune cells has a different prognostic role in breast cancer; however, the prognostic impact of tumor-infiltrating natural killer cells (TINKs) is still not well established. Our aim was to assess the prognostic impact of natural killer (NK) cells in breast carcinomas. MATERIALS AND METHODS: NK cells infiltration were assessed by immunohistochemistry (IHC). Statistical analyses were performed to evaluate the correlation of NK cells with clinical-pathological features and outcome. RESULTS: CD56 IHC was realized in 126 patients. NK cells infiltration showed significant and positive association with tumor high Scarff-Bloom-Richardson (SBR) grade. NK cells were significantly associated with HER2-positive breast cancer and triple-negative breast cancer subtypes. Analyses showed significant and inverse correlation with progesterone and estrogen receptors expression status. High NK cells were significantly related to high Ki-67 labeling index. Our data showed that high NK cells infiltrate was significantly associated with tumor-infiltrating lymphocytes in breast cancer tissues. At a median follow-up of 5.5 years, high CD56 expression (≥ 5 cells/10 high power field) was associated significantly with a good overall survival and with good disease-free survival. CONCLUSION: In this study, we assessed the important prognostic role of TINKs in breast carcinomas, which seems to be evident despite its association with aggressive pathological features. Thus evaluation of NK cells can be standardized and integrated in daily routine.
Authors: Hongxiao Li; Jigang Wang; Zaibo Li; Melad Dababneh; Fusheng Wang; Peng Zhao; Geoffrey H Smith; George Teodoro; Meijie Li; Jun Kong; Xiaoxian Li Journal: Front Med (Lausanne) Date: 2022-06-14
Authors: Guang He Ran; Yu Qing Lin; Lei Tian; Tao Zhang; Dong Mei Yan; Jian Hua Yu; You Cai Deng Journal: Signal Transduct Target Ther Date: 2022-06-29