Literature DB >> 33725255

Activation of TLR4 of Mesenchymal Stem Cells Enhances the Regenerative Properties of Their Secretomes.

A L Rusanov1, Yu K Biryukova2, O O Shoshina2, E D Luzgina3, N G Luzgina3.   

Abstract

Mesenchymal stem cells (MSC), like macrophages, can be polarized in vitro. In particular, activation of type 4 Toll-like receptor in MSC leads to the appearance of the so-called "proinflammatory" MSC phenotype (MSC1). We showed that secretome (conditioned media) of MSC1 can affect the wound healing processes: promote healing and modulate exudative inflammation and subsequent fibroplastic processes in the damaged area. These effects of secretomes of polarized MSC were superior to those of intact MSC.

Entities:  

Keywords:  cell secretomes; inflammatory infiltrates; phenotype of mesenchymal stem cells; wound healing process; “proinflammatory” cell phenotype

Year:  2021        PMID： 33725255     DOI： 10.1007/s10517-021-05103-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  9 in total

1.  Prospect of Using Cell Product for the Therapy of Skin Defects in Diabetes Mellitus.

Authors:  A P Lykov; N A Bondarenko; O V Poveshchenko; T V Miller; A F Poveshchenko; M A Surovtseva; N P Bgatova; V I Konenkov
Journal:  Bull Exp Biol Med       Date:  2017-11-25       Impact factor: 0.804

2.  Cholecystokinin in the cat retina. Action of exogenous CCK8 and localization of cholecystokinin-like immunoreactivity.

Authors:  P Thier; J Bolz
Journal:  Invest Ophthalmol Vis Sci       Date:  1985-03       Impact factor: 4.799

3.  Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging.

Authors:  Byung-Soon Park; Kyoung Ae Jang; Jong-Hyuk Sung; Jeong-Soo Park; Yong Hyun Kwon; Kea Jeong Kim; Won-Serk Kim
Journal:  Dermatol Surg       Date:  2008-06-27       Impact factor: 3.398

4.  Interleukin 2 production by human T lymphocytes identified by antibodies to dipeptidyl peptidase IV.

Authors:  W Scholz; R Mentlein; E Heymann; A C Feller; A J Ulmer; H D Flad
Journal:  Cell Immunol       Date:  1985-06       Impact factor: 4.868

5.  Effect of oxidized dextran on reparative regeneration of the skin after burn injury.

Authors:  V A Shkurupiy; M A Karpov; N G Luzgina
Journal:  Bull Exp Biol Med       Date:  2012-09       Impact factor: 0.804

6.  Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages.

Authors:  Dong-Im Cho; Mi Ra Kim; Hye-yun Jeong; Hae Chang Jeong; Myung Ho Jeong; Sung Ho Yoon; Yong Sook Kim; Youngkeun Ahn
Journal:  Exp Mol Med       Date:  2014-01-10       Impact factor: 8.718

Review 7.  Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy.

Authors:  Alison Wilson; Margeaux Hodgson-Garms; Jessica E Frith; Paul Genever
Journal:  Front Immunol       Date:  2019-05-16       Impact factor: 7.561

8.  Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing.

Authors:  Liwen Chen; Edward E Tredget; Philip Y G Wu; Yaojiong Wu
Journal:  PLoS One       Date:  2008-04-02       Impact factor: 3.240

9.  Human umbilical cord mesenchymal stem cells transplantation promotes cutaneous wound healing of severe burned rats.

Authors:  Lingying Liu; Yonghui Yu; Yusen Hou; Jiake Chai; Hongjie Duan; Wanli Chu; Haijun Zhang; Quan Hu; Jundong Du
Journal:  PLoS One       Date:  2014-02-20       Impact factor: 3.240
  9 in total

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