INTRODUCTION: Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have been identified in retirement nursing homes, with a high number of deaths. Our study aims were to evaluate the spread of SARS-CoV-2 in the retirement nursing homes, the predictors to develop symptoms, and death. METHODS AND FINDINGS: We conducted a retrospective study enrolling all people living in retirement nursing homes (PLRNH), where at least one SARS-CoV-2 infected person was present. Medical and clinical data were collected. Variables were compared with Student's t-test or Pearson chi-square test as appropriate. Uni- and multivariate analyses were conducted to evaluate variables' influence on infection and symptoms development. Cox proportional-hazards model was used to evaluate 30 days mortality predictors, considering death as the dependent variable. We enrolled 382 subjects. The mean age was 81.15±10.97 years, and males were 140(36.7%). At the multivariate analysis, mental disorders, malignancies, and angiotensin II receptor blockers were predictors of SARS-CoV-2 infection while having a neurological syndrome was associated with a lower risk. Only half of the people with SARS-CoV-2 infection developed symptoms. Chronic obstructive pulmonary disease and neurological syndrome were correlated with an increased risk of developing SARS-CoV-2 related symptoms. Fifty-six (21.2%) people with SARS-CoV-2 infection died; of these, 53 died in the first 30 days after the swab's positivity. Significant factors associated with 30-days mortality were male gender, hypokinetic disease, and the presence of fever and dyspnea. Patients' autonomy and early heparin treatment were related to lower mortality risk. CONCLUSIONS: We evidenced factors associated with infection's risk and death in a setting with high mortality such as retirement nursing homes, that should be carefully considered in the management of PLRNH.
INTRODUCTION: Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have been identified in retirement nursing homes, with a high number of deaths. Our study aims were to evaluate the spread of SARS-CoV-2 in the retirement nursing homes, the predictors to develop symptoms, and death. METHODS AND FINDINGS: We conducted a retrospective study enrolling all people living in retirement nursing homes (PLRNH), where at least one SARS-CoV-2 infected person was present. Medical and clinical data were collected. Variables were compared with Student's t-test or Pearson chi-square test as appropriate. Uni- and multivariate analyses were conducted to evaluate variables' influence on infection and symptoms development. Cox proportional-hazards model was used to evaluate 30 days mortality predictors, considering death as the dependent variable. We enrolled 382 subjects. The mean age was 81.15±10.97 years, and males were 140(36.7%). At the multivariate analysis, mental disorders, malignancies, and angiotensin II receptor blockers were predictors of SARS-CoV-2 infection while having a neurological syndrome was associated with a lower risk. Only half of the people with SARS-CoV-2 infection developed symptoms. Chronic obstructive pulmonary disease and neurological syndrome were correlated with an increased risk of developing SARS-CoV-2 related symptoms. Fifty-six (21.2%) people with SARS-CoV-2 infection died; of these, 53 died in the first 30 days after the swab's positivity. Significant factors associated with 30-days mortality were male gender, hypokinetic disease, and the presence of fever and dyspnea. Patients' autonomy and early heparin treatment were related to lower mortality risk. CONCLUSIONS: We evidenced factors associated with infection's risk and death in a setting with high mortality such as retirement nursing homes, that should be carefully considered in the management of PLRNH.
Authors: Saad Alhumaid; Abbas Al Mutair; Zainab Al Alawi; Khulud Al Salman; Nourah Al Dossary; Ahmed Omar; Mossa Alismail; Ali M Al Ghazal; Mahdi Bu Jubarah; Hanan Al Shaikh; Maher M Al Mahdi; Sarah Y Alsabati; Dayas K Philip; Mohammed Y Alyousef; Abdulsatar H Al Brahim; Maitham S Al Athan; Salamah A Alomran; Hatim S Ahmed; Haifa Al-Shammari; Alyaa Elhazmi; Ali A Rabaan; Jaffar A Al-Tawfiq; Awad Al-Omari Journal: Eur J Med Res Date: 2021-05-24 Impact factor: 2.175
Authors: Raymond Pranata; Ian Huang; Michael Anthonius Lim; Emir Yonas; Rachel Vania; Antonia Anna Lukito; Sally Aman Nasution; Bambang Budi Siswanto; Raden A Tuty Kuswardhani Journal: Front Med (Lausanne) Date: 2021-12-22
Authors: Muriel Rabilloud; Benjamin Riche; Jean François Etard; Mad-Hélénie Elsensohn; Nicolas Voirin; Thomas Bénet; Jean Iwaz; René Ecochard; Philippe Vanhems Journal: PLoS One Date: 2022-01-07 Impact factor: 3.240
Authors: Jae-Kwang Lim; Byunggeon Park; Jongmin Park; Keum-Ju Choi; Chi-Young Jung; Young Hwan Kim; Jin Young Kim; Sungjun Moon; Yong Hoon Lee; Jaehee Lee Journal: Int J Gen Med Date: 2021-07-12