Marianne Canonico1, Giancarlo Pesce1, Audrey Bonaventure2, Maryline Le Noan-Lainé1, Isabelle Benatru3, Danièle Ranoux4, Frédéric Moisan5, Alexis Elbaz1. 1. Paris-Saclay University, Paris-South University, UVSQ, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France. 2. CRESS, Université de Paris INSERM, UMR 1153, Epidemiology of Childhood and Adolescent Cancers Team, Villejuif, France. 3. Neurology Department, University Hospital of Poitiers, Poitiers, France. 4. Pain center, CHU Dupuytren, 2 bis avenue Martin Luther King, 87000 Limoges and Pain center, Fondation Adolphe de Rothschild, 28 rue Manin, Paris, 75019, France. 5. Santé Publique France, Direction Santé Environnement et Travail, Saint Maurice, France.
Abstract
BACKGROUND: Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous. OBJECTIVES: To investigate the association of reproductive life characteristics with PD among postmenopausal women. METHODS: The PARTAGE case-control included 130 female cases and 255 age-matched female controls. Information on gynecological history was obtained from a standardized questionnaire and PD was validated by neurological examination. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. RESULTS: After adjustment for education level, smoking status, professional exposure to pesticides, and coffee and alcohol drinking, bilateral oophorectomy (OR = 3.55, 95%CI = 1.75-7.20), but neither menopause before age 50 years (OR = 1.24, 95%CI = 0.74-2.09) nor hormone therapy (HT; OR = 1.07, 95%CI = 0.62-1.86), was associated with PD. CONCLUSION: Our findings suggest that bilateral oophorectomy is associated with increased risk of PD.
BACKGROUND: Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous. OBJECTIVES: To investigate the association of reproductive life characteristics with PD among postmenopausal women. METHODS: The PARTAGE case-control included 130 female cases and 255 age-matched female controls. Information on gynecological history was obtained from a standardized questionnaire and PD was validated by neurological examination. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. RESULTS: After adjustment for education level, smoking status, professional exposure to pesticides, and coffee and alcohol drinking, bilateral oophorectomy (OR = 3.55, 95%CI = 1.75-7.20), but neither menopause before age 50 years (OR = 1.24, 95%CI = 0.74-2.09) nor hormone therapy (HT; OR = 1.07, 95%CI = 0.62-1.86), was associated with PD. CONCLUSION: Our findings suggest that bilateral oophorectomy is associated with increased risk of PD.
Authors: Zachary Erickson; Walter A Rocca; Carin Y Smith; Liliana Gazzuola Rocca; Elizabeth A Stewart; Shannon K Laughlin-Tommaso; Michelle M Mielke Journal: Obstet Gynecol Date: 2022-04-05 Impact factor: 7.623