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Literature DB >> 3372453

Platelet size, number, and serotonin content in blood of autistic, childhood schizophrenic, and normal children.

E Geller¹, A Yuwiler, B J Freeman, E Ritvo.

Abstract

Platelet volumes were measured in 19 autistic, 26 normal, and 6 schizophrenic children with similar blood serotonin concentrations. The groups did not significantly differ in platelet volumes, nor did platelet volumes and blood serotonin concentrations correlate. These results do not support the hypothesis that the hyperserotoninemia in some autistics reflects increased platelet volume.

Entities: Chemical Disease Species

Mesh：

Substances：
Serotonin

Year: 1988 PMID： 3372453 DOI： 10.1007/bf02211822

Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257

13 in total

1. Research diagnostic criteria.

Authors: R L Spitzer; J Endicott; E Robins
Journal: Psychopharmacol Bull Date: 1975-07

2. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.

Authors: R J SCHAIN; D X FREEDMAN
Journal: J Pediatr Date: 1961-03 Impact factor: 4.406

3. Blood serotonin in psychotic and brain damaged children.

Authors: M Campbell; E Friedman; E DeVito; L Greenspan; P J Collins
Journal: J Autism Child Schizophr Date: 1974 Jan-Mar

4. Separation of erythrocytes according to age on a simplified density gradient.

Authors: L M Corash; S Piomelli; H C Chen; C Seaman; E Gross
Journal: J Lab Clin Med Date: 1974-07

5. Increased blood serotonin and platelets in early infantile autism.

Authors: E R Ritvo; A Yuwiler; E Geller; E M Ornitz; K Saeger; S Plotkin
Journal: Arch Gen Psychiatry Date: 1970-12

6. Platelet size in man.

Authors: J M Paulus
Journal: Blood Date: 1975-09 Impact factor: 22.113

7. Reassessment of elevated serotonin levels in blood platelets in early infantile autism.

Authors: S Takahashi; H Kanai; Y Miyamoto
Journal: J Autism Child Schizophr Date: 1976-12

8. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure.

Authors: L Corash; H Tan; H R Gralnick
Journal: Blood Date: 1977-01 Impact factor: 22.113

Platelet size, number, and serotonin content in blood of autistic, childhood schizophrenic, and normal children.

1. Research diagnostic criteria.

2. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.

3. Blood serotonin in psychotic and brain damaged children.

4. Separation of erythrocytes according to age on a simplified density gradient.

5. Increased blood serotonin and platelets in early infantile autism.

6. Platelet size in man.

7. Reassessment of elevated serotonin levels in blood platelets in early infantile autism.

8. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure.

9. A rapid accurate procedure for the determination of serotonin in whole human blood.

10. Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes.

1. Platelet serotonin, a possible marker for familial autism.

2. The issue of hyperserotonemia and platelet serotonin exposure: a preliminary study.

Review 3. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.

4. The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder.

5. Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives".

6. Platelet studies in autism spectrum disorder patients and first-degree relatives.