Chiara Kirchler1, Emma Husar-Memmer2, Klemens Rappersberger3, Kylie Thaler2, Ruth Fritsch-Stork4. 1. School of Medicine, Sigmund Freud University Vienna, Vienna, Austria. Electronic address: 01105128@mail.sfu.ac.at. 2. 1st Medical Department, Hanusch Hospital of the Austrian Health Insurance Fund, Vienna, Austria. 3. School of Medicine, Sigmund Freud University Vienna, Vienna, Austria; Department of Dermatology and Venerology, The Rudolfstiftung Hospital, Vienna, Austria. 4. School of Medicine, Sigmund Freud University Vienna, Vienna, Austria; 1st Medical Department, Hanusch Hospital of the Austrian Health Insurance Fund, Vienna, Austria; Ludwig Boltzmann Institute of Osteology, Hanusch Hospital and AUVA Trauma Center Meidling, Vienna, Austria.
Abstract
OBJECTIVE: Patients with systemic lupus erythematosus (SLE) have a high burden of cardiovascular disease (CVD) of multifactorial origin. The aim of this systematic review is to analyze the role of the interferon I (IFN-I) signature and fibroblast growth factor-23 (FGF-23) in patients with SLE or cutaneous lupus erythematosus (CLE) herein. MATERIALS AND METHODS: We conducted a systematic literature search in PubMed and Scopus using keywords for major adverse cardiovascular events (MACE) and intermediate outcomes (endothelial dysfunction, subclinical atherosclerosis, platelet activation) associated with IFN-I or FGF-23 in patients with SLE and CLE. RESULTS: 4745 citations were screened, of which 12 studies were included. IFN-I was associated with MACE in two third of the studies and the association was strongest for cardiac events. An association of IFN-I was found in all studies investigating impaired vascular function, but only in 50% (respectively 40%) of reports examining the relation of IFN-I and platelet activation (respectively subclinical atherosclerosis). Altogether the reports were of variable bias and quality due to high variability of examined IFN-I biomarkers and inconsistent results for different outcome measures. No studies investigating the cardiovascular risk of circulating IFN-I in CLE, nor FGF-23 in SLE or CLE were found. CONCLUSION: Clinical studies measuring the association between IFN-I and direct / intermediate measures of CVD are rare and ambiguous in SLE and nonexistent in CLE, hampering a definite conclusion.
OBJECTIVE:Patients with systemic lupus erythematosus (SLE) have a high burden of cardiovascular disease (CVD) of multifactorial origin. The aim of this systematic review is to analyze the role of the interferon I (IFN-I) signature and fibroblast growth factor-23 (FGF-23) in patients with SLE or cutaneous lupus erythematosus (CLE) herein. MATERIALS AND METHODS: We conducted a systematic literature search in PubMed and Scopus using keywords for major adverse cardiovascular events (MACE) and intermediate outcomes (endothelial dysfunction, subclinical atherosclerosis, platelet activation) associated with IFN-I or FGF-23 in patients with SLE and CLE. RESULTS: 4745 citations were screened, of which 12 studies were included. IFN-I was associated with MACE in two third of the studies and the association was strongest for cardiac events. An association of IFN-I was found in all studies investigating impaired vascular function, but only in 50% (respectively 40%) of reports examining the relation of IFN-I and platelet activation (respectively subclinical atherosclerosis). Altogether the reports were of variable bias and quality due to high variability of examined IFN-I biomarkers and inconsistent results for different outcome measures. No studies investigating the cardiovascular risk of circulating IFN-I in CLE, nor FGF-23 in SLE or CLE were found. CONCLUSION: Clinical studies measuring the association between IFN-I and direct / intermediate measures of CVD are rare and ambiguous in SLE and nonexistent in CLE, hampering a definite conclusion.
Authors: Abdulrahman N Shams-Eldin; Adelina Yafasova; Mikkel Faurschou; Morten Schou; Guoli Sun; Gunnar H Gislason; Christian Torp-Pedersen; Emil L Fosbøl; Lars Køber; Jawad H Butt Journal: Clin Rheumatol Date: 2022-07-30 Impact factor: 3.650
Authors: Yuzhou Gan; Yawei Zhao; Gongming Li; Hua Ye; Yunshan Zhou; Chang Hou; Lan Wang; Jianping Guo; Chun Li Journal: Front Cardiovasc Med Date: 2022-07-05