Kyung Hoon Min1, Chin Kook Rhee2, Hyonsoo Joo3, Seoung Ju Park4. 1. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul, 08308, Republic of Korea. minkyunghoon@korea.ac.kr. 2. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seochogu, Seoul, 06591, Republic of Korea. chinkook77@gmail.com. 3. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 4. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
Abstract
BACKGROUND: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD. METHODS: Plasma IL-33 was measured in 62 COPD patients during their stable state. Patients were prospectively followed up for 1 year. The expression of IL-33 was measured in lung tissue obtained from 38 patients who underwent surgery. RESULTS: The number of exacerbations was significantly higher in the high plasma IL-33 group compared with the low plasma IL-33 group. On Poisson regression analysis, high plasma IL-33 was associated with increased risk of exacerbation (incidence rate ratio = 2.166, P = 0.043). The expression of IL-33 in the lung was higher in COPD patients than in controls. The expression of IL-33 was significantly correlated with smoking pack years (R = 0.45, P < 0.01) and Forced expiratory volume in 1 s (%) (R = - 0.58, P < 0.01). CONCLUSION: The plasma level of IL-33 in patients with COPD was significantly associated with the risk of exacerbation in prospective follow up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function.
BACKGROUND: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD. METHODS: Plasma IL-33 was measured in 62 COPDpatients during their stable state. Patients were prospectively followed up for 1 year. The expression of IL-33 was measured in lung tissue obtained from 38 patients who underwent surgery. RESULTS: The number of exacerbations was significantly higher in the high plasma IL-33 group compared with the low plasma IL-33 group. On Poisson regression analysis, high plasma IL-33 was associated with increased risk of exacerbation (incidence rate ratio = 2.166, P = 0.043). The expression of IL-33 in the lung was higher in COPDpatients than in controls. The expression of IL-33 was significantly correlated with smoking pack years (R = 0.45, P < 0.01) and Forced expiratory volume in 1 s (%) (R = - 0.58, P < 0.01). CONCLUSION: The plasma level of IL-33 in patients with COPD was significantly associated with the risk of exacerbation in prospective follow up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function.
Authors: Jennifer Kearley; Jonathan S Silver; Caroline Sanden; Zheng Liu; Aaron A Berlin; Natalie White; Michiko Mori; Tuyet-Hang Pham; Christine K Ward; Gerard J Criner; Nathaniel Marchetti; Tomas Mustelin; Jonas S Erjefalt; Roland Kolbeck; Alison A Humbles Journal: Immunity Date: 2015-03-17 Impact factor: 31.745
Authors: David Préfontaine; Stéphane Lajoie-Kadoch; Susan Foley; Séverine Audusseau; Ron Olivenstein; Andrew J Halayko; Catherine Lemière; James G Martin; Qutayba Hamid Journal: J Immunol Date: 2009-10-15 Impact factor: 5.422
Authors: Derek E Byers; Jennifer Alexander-Brett; Anand C Patel; Eugene Agapov; Geoffrey Dang-Vu; Xiaohua Jin; Kangyun Wu; Yingjian You; Yael Alevy; Jean-Philippe Girard; Thaddeus S Stappenbeck; G Alexander Patterson; Richard A Pierce; Steven L Brody; Michael J Holtzman Journal: J Clin Invest Date: 2013-08-15 Impact factor: 14.808
Authors: Damian Tworek; Sebastian Majewski; Karolina Szewczyk; Justyna Kiszałkiewicz; Zofia Kurmanowska; Paweł Górski; Ewa Brzeziańska-Lasota; Piotr Kuna; Adam Antczak Journal: Respir Res Date: 2018-06-01