Literature DB >> 33721552

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task.

Hongdian Yang1, Bilal A Bari2, Jeremiah Y Cohen2, Daniel H O'Connor2.   

Abstract

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
© 2021, Yang et al.

Entities:  

Keywords:  S1; locus coeruleus; mouse; neuroscience; norepinephrine; pupil; somatosensory cortex; tactile

Year:  2021        PMID： 33721552      PMCID： PMC7963470          DOI： 10.7554/eLife.64327

Source DB:  PubMed          Journal:  Elife        ISSN： 2050-084X            Impact factor:   8.140


  40 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

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Journal:  Prog Brain Res       Date:  1991       Impact factor: 2.453

7.  Locus coeruleus activity in monkey: phasic and tonic changes are associated with altered vigilance.

Authors:  J Rajkowski; P Kubiak; G Aston-Jones
Journal:  Brain Res Bull       Date:  1994       Impact factor: 4.077

8.  Structure of layer IV in the somatosensory neocortex of the rat: description and comparison with the mouse.

Authors:  C Welker; T A Woolsey
Journal:  J Comp Neurol       Date:  1974-12-15       Impact factor: 3.215

9.  Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics.

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2.  Pupil diameter is not an accurate real-time readout of locus coeruleus activity.

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Journal:  Elife       Date:  2022-02-02       Impact factor: 8.140

3.  Pupil Correlates of Decision Variables in Mice Playing a Competitive Mixed-Strategy Game.

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Review 4.  The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.

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Review 5.  The Neuroscience of the Flow State: Involvement of the Locus Coeruleus Norepinephrine System.

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  5 in total

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