| Literature DB >> 33721239 |
Ruth Edge1, T George Truscott2.
Abstract
A hypothesis is proposed to explain the increased detrimental effect of COVID-19 for Black, Asian and Minority Ethnic (BAME) men and women compared to Caucasian individuals. This is based on the differing photochemistry of phaeomelanin in fair skin and eumelanin in dark/black skin. It is suggested that a range of reactive oxygen species, including, singlet oxygen and the superoxide radical anion, derived via direct photolysis of phaeomelanin, may escape the melanocyte and cause subsequent damage to the SARS-CoV-2 virus. It is further suggested that (large) carbon and sulphur peroxy radicals, from oxygen addition to radicals formed by carbon-sulphur bond cleavage, may assist via damage to the cell membranes. It is also speculated that light absorption by phaeomelanin and the subsequent C-S bond cleavage, leads to release of pre-absorbed reactive oxygen species, such as singlet oxygen and free radicals, which may also contribute to an enhanced protective effect for fair-skinned people.Entities:
Keywords: COVID-19; Coronavirus; Free radicals; Phaeomelanin; Sars-CoV-2
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Year: 2021 PMID: 33721239 PMCID: PMC7791943 DOI: 10.1007/s43630-020-00004-8
Source DB: PubMed Journal: Photochem Photobiol Sci ISSN: 1474-905X Impact factor: 3.982