Literature DB >> 33721239

COVID-19 and the ethnicity link - is there a photochemical link?

Ruth Edge1, T George Truscott2.   

Abstract

A hypothesis is proposed to explain the increased detrimental effect of COVID-19 for Black, Asian and Minority Ethnic (BAME) men and women compared to Caucasian individuals. This is based on the differing photochemistry of phaeomelanin in fair skin and eumelanin in dark/black skin. It is suggested that a range of reactive oxygen species, including, singlet oxygen and the superoxide radical anion, derived via direct photolysis of phaeomelanin, may escape the melanocyte and cause subsequent damage to the SARS-CoV-2 virus. It is further suggested that (large) carbon and sulphur peroxy radicals, from oxygen addition to radicals formed by carbon-sulphur bond cleavage, may assist via damage to the cell membranes. It is also speculated that light absorption by phaeomelanin and the subsequent C-S bond cleavage, leads to release of pre-absorbed reactive oxygen species, such as singlet oxygen and free radicals, which may also contribute to an enhanced protective effect for fair-skinned people.

Entities:  

Keywords:  COVID-19; Coronavirus; Free radicals; Phaeomelanin; Sars-CoV-2

Mesh:

Substances:

Year:  2021        PMID: 33721239      PMCID: PMC7791943          DOI: 10.1007/s43630-020-00004-8

Source DB:  PubMed          Journal:  Photochem Photobiol Sci        ISSN: 1474-905X            Impact factor:   3.982


  29 in total

1.  Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: selective protein oxidation during biological aging.

Authors:  Victor S Sharov; Elena S Dremina; Nadezhda A Galeva; Todd D Williams; Christian Schöneich
Journal:  Biochem J       Date:  2006-03-15       Impact factor: 3.857

2.  A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene.

Authors:  Fritz Boehm; Ruth Edge; Terence George Truscott; Christian Witt
Journal:  FEBS Lett       Date:  2016-03-29       Impact factor: 4.124

3.  Covid-19 and ethnic minorities: an urgent agenda for overdue action.

Authors:  Kamlesh Khunti; Lucinda Platt; Ash Routen; Kamran Abbasi
Journal:  BMJ       Date:  2020-06-23

Review 4.  Photodegradation of Eumelanin and Pheomelanin and Its Pathophysiological Implications.

Authors:  Shosuke Ito; Kazumasa Wakamatsu; Tadeusz Sarna
Journal:  Photochem Photobiol       Date:  2017-10-26       Impact factor: 3.421

5.  UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy.

Authors:  Nick Kassouf; Christopher W M Kay; Arsen Volkov; Shih-Chieh Chiang; Mark A Birch-Machin; Sherif F El-Khamisy; Rachel M Haywood
Journal:  Free Radic Biol Med       Date:  2018-07-25       Impact factor: 7.376

6.  Skin type differences in solar-simulated radiation-induced oxidative stress.

Authors:  S Albrecht; S Jung; R Müller; J Lademann; T Zuberbier; L Zastrow; C Reble; I Beckers; M C Meinke
Journal:  Br J Dermatol       Date:  2018-10-14       Impact factor: 9.302

7.  Singlet oxygen quenching by dietary carotenoids in a model membrane environment.

Authors:  Ann Cantrell; D J McGarvey; T George Truscott; Fiorenza Rancan; Fritz Böhm
Journal:  Arch Biochem Biophys       Date:  2003-04-01       Impact factor: 4.013

8.  Ion-exchange and adsorption of Fe(III) by Sepia melanin.

Authors:  Yan Liu; Lian Hong; Valerie R Kempf; Kazumasa Wakamatsu; Shosuke Ito; John D Simon
Journal:  Pigment Cell Res       Date:  2004-06

9.  Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.

Authors:  George Goshua; Alexander B Pine; Matthew L Meizlish; C-Hong Chang; Hanming Zhang; Parveen Bahel; Audrey Baluha; Noffar Bar; Robert D Bona; Adrienne J Burns; Charles S Dela Cruz; Anne Dumont; Stephanie Halene; John Hwa; Jonathan Koff; Hope Menninger; Natalia Neparidze; Christina Price; Jonathan M Siner; Christopher Tormey; Henry M Rinder; Hyung J Chun; Alfred I Lee
Journal:  Lancet Haematol       Date:  2020-06-30       Impact factor: 18.959

10.  Vitamin D concentrations and COVID-19 infection in UK Biobank.

Authors:  Claire E Hastie; Daniel F Mackay; Frederick Ho; Carlos A Celis-Morales; Srinivasa Vittal Katikireddi; Claire L Niedzwiedz; Bhautesh D Jani; Paul Welsh; Frances S Mair; Stuart R Gray; Catherine A O'Donnell; Jason Mr Gill; Naveed Sattar; Jill P Pell
Journal:  Diabetes Metab Syndr       Date:  2020-05-07
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