Literature DB >> 33717605

Metabolism in Invariant Natural Killer T Cells: An Overview.

Emily L Yarosz1, Cheong-Hee Chang1,2, Ajay Kumar2.   

Abstract

Cellular metabolism is critical for generating energy and macromolecules for cell growth and survival. In recent years, the importance of metabolism in mediating T cell differentiation, proliferation, and function has been a hot topic of investigation. However, very little is known about metabolic regulation in invariant natural killer T (iNKT) cells. In this viewpoint, we will discuss what is currently known about immunometabolism in iNKT cells and how these findings relate to CD4 T cells.

Entities:  

Keywords:  CD4 T cells; OXPHOS; cell proliferation; fatty acid synthesis; glycolysis; iNKT cells; metabolism

Year:  2021        PMID： 33717605      PMCID： PMC7951988          DOI： 10.20900/immunometab20210010

Source DB:  PubMed          Journal:  Immunometabolism


  53 in total

1.  Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Authors:  Katrin Düvel; Jessica L Yecies; Suchithra Menon; Pichai Raman; Alex I Lipovsky; Amanda L Souza; Ellen Triantafellow; Qicheng Ma; Regina Gorski; Stephen Cleaver; Matthew G Vander Heiden; Jeffrey P MacKeigan; Peter M Finan; Clary B Clish; Leon O Murphy; Brendan D Manning
Journal:  Mol Cell       Date:  2010-07-30       Impact factor: 17.970

2.  Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Authors:  Nicolas Prevot; Kalyani Pyaram; Evan Bischoff; Jyoti Misra Sen; Jonathan D Powell; Cheong-Hee Chang
Journal:  J Immunol       Date:  2014-11-17       Impact factor: 5.422

3.  Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development.

Authors:  Heon Park; Mark Tsang; Brian M Iritani; Michael J Bevan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-30       Impact factor: 11.205

4.  Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.

Authors:  Kalyani Pyaram; Ajay Kumar; Yeung-Hyen Kim; Sanjeev Noel; Sekhar P Reddy; Hamid Rabb; Cheong-Hee Chang
Journal:  Cell Rep       Date:  2019-04-16       Impact factor: 9.423

5.  Diverse TCRs recognize murine CD1.

Authors:  S M Behar; T A Podrebarac; C J Roy; C R Wang; M B Brenner
Journal:  J Immunol       Date:  1999-01-01       Impact factor: 5.422

6.  Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

Authors:  Nelson M LaMarche; Harry Kane; Ayano C Kohlgruber; Han Dong; Lydia Lynch; Michael B Brenner
Journal:  Cell Metab       Date:  2020-06-08       Impact factor: 27.287

7.  Emerging concepts of T cell metabolism as a target of immunotherapy.

Authors:  Chih-Hao Chang; Erika L Pearce
Journal:  Nat Immunol       Date:  2016-04       Impact factor: 25.606

Review 8.  Tissue-specific functions of invariant natural killer T cells.

Authors:  Catherine M Crosby; Mitchell Kronenberg
Journal:  Nat Rev Immunol       Date:  2018-09       Impact factor: 53.106

9.  Combination therapy of in vitro-expanded natural killer T cells and alpha-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma.

Authors:  Naoki Kunii; Shigetoshi Horiguchi; Shinichiro Motohashi; Heizaburo Yamamoto; Naoyuki Ueno; Seiji Yamamoto; Daiju Sakurai; Masaru Taniguchi; Toshinori Nakayama; Yoshitaka Okamoto
Journal:  Cancer Sci       Date:  2009-03-11       Impact factor: 6.716

Review 10.  Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation.

Authors:  Suyasha Roy; Zaigham Abbas Rizvi; Amit Awasthi
Journal:  Front Immunol       Date:  2019-01-14       Impact factor: 7.561
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  1 in total

Review 1.  Metabolic regulation of T cell development.

Authors:  Mengdi Zhang; Xiaoxi Lin; Zhou Yang; Xia Li; Zhiguang Zhou; Paul E Love; Jiaqi Huang; Bin Zhao
Journal:  Front Immunol       Date:  2022-07-25       Impact factor: 8.786
  1 in total

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