Literature DB >> 33717153

The Macroautophagy Machinery in MHC Restricted Antigen Presentation.

Christian Münz1.   

Abstract

Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. Here, I summarize how these different pathways use the macroautophagy machinery, contribute to MHC class I and II restricted antigen presentation and influence autoimmunity, tumor immunology and immune control of infectious diseases. Targeting these different pathways should allow the regulation of intracellular and extracellular antigen presentation to T cells to modulate protective and pathological immune responses.
Copyright © 2021 Münz.

Entities:  

Keywords:  LC3-associated phagocytosis; cross-presentation; cytotoxic CD8+ T cells; exocytosis; helper CD4+ T cells

Mesh：

Substances：

Year:  2021        PMID： 33717153      PMCID： PMC7947692          DOI： 10.3389/fimmu.2021.628429

Source DB:  PubMed          Journal:  Front Immunol        ISSN： 1664-3224            Impact factor:   7.561


  75 in total

1.  Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.

Authors:  Oliver Florey; Sung Eun Kim; Cynthia P Sandoval; Cole M Haynes; Michael Overholtzer
Journal:  Nat Cell Biol       Date:  2011-10-16       Impact factor: 28.824

Review 2.  Cell biology of antigen processing in vitro and in vivo.

Authors:  E Sergio Trombetta; Ira Mellman
Journal:  Annu Rev Immunol       Date:  2005       Impact factor: 28.527

3.  First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules.

Authors:  Anish Suri; James J Walters; Henry W Rohrs; Michael L Gross; Emil R Unanue
Journal:  J Immunol       Date:  2008-03-15       Impact factor: 5.422

4.  Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.

Authors:  Pauline Verlhac; Isabel P Grégoire; Olga Azocar; Denitsa S Petkova; Joël Baguet; Christophe Viret; Mathias Faure
Journal:  Cell Host Microbe       Date:  2015-03-12       Impact factor: 21.023

5.  Author Correction: Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.

Authors:  Kazuaki Matoba; Tetsuya Kotani; Akihisa Tsutsumi; Takuma Tsuji; Takaharu Mori; Daisuke Noshiro; Yuji Sugita; Norimichi Nomura; So Iwata; Yoshinori Ohsumi; Toyoshi Fujimoto; Hitoshi Nakatogawa; Masahide Kikkawa; Nobuo N Noda
Journal:  Nat Struct Mol Biol       Date:  2020-12       Impact factor: 15.369

Review 6.  Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

Authors:  Vladimir Rogov; Volker Dötsch; Terje Johansen; Vladimir Kirkin
Journal:  Mol Cell       Date:  2014-01-23       Impact factor: 17.970

7.  Unconventional secretion of Acb1 is mediated by autophagosomes.

Authors:  Juan M Duran; Christophe Anjard; Chris Stefan; William F Loomis; Vivek Malhotra
Journal:  J Cell Biol       Date:  2010-02-15       Impact factor: 10.539

8.  Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

Authors:  Wouter Pos; Dhruv K Sethi; Melissa J Call; Monika-Sarah E D Schulze; Anne-Kathrin Anders; Jason Pyrdol; Kai W Wucherpfennig
Journal:  Cell       Date:  2012-12-21       Impact factor: 41.582

9.  The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.

Authors:  Jean Francois Fonteneau; Fabienne Brilot; Christian Münz; Monique Gannagé
Journal:  J Immunol       Date:  2015-11-25       Impact factor: 5.422

10.  The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.

Authors:  Andrew M Leidal; Hector H Huang; Timothy Marsh; Tina Solvik; Dachuan Zhang; Jordan Ye; FuiBoon Kai; Juliet Goldsmith; Jennifer Y Liu; Yu-Hsin Huang; Teresa Monkkonen; Ariadne Vlahakis; Eric J Huang; Hani Goodarzi; Li Yu; Arun P Wiita; Jayanta Debnath
Journal:  Nat Cell Biol       Date:  2020-01-13       Impact factor: 28.824
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  6 in total

Review 1.  Autophagy in cancer cell remodeling and quality control.

Authors:  Grace A Hernandez; Rushika M Perera
Journal:  Mol Cell       Date:  2022-04-21       Impact factor: 19.328

Review 2.  Antigen Presentation and Autophagy in Teleost Adaptive Immunity.

Authors:  Carolina Johnstone; Elena Chaves-Pozo
Journal:  Int J Mol Sci       Date:  2022-04-28       Impact factor: 6.208

3.  MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.

Authors:  David Possamaï; Laïla-Aïcha Hanafi; Angélique Bellemare-Pelletier; Katia Hamelin; Paméla Thébault; Marie-Josée Hébert; Étienne Gagnon; Denis Leclerc; Réjean Lapointe
Journal:  PLoS One       Date:  2021-12-31       Impact factor: 3.240

Review 4.  Research progress on the relationship between autophagy and chronic complications of diabetes.

Authors:  Xia Ge; Ling Wang; Aihua Fei; Shandong Ye; Qingping Zhang
Journal:  Front Physiol       Date:  2022-08-08       Impact factor: 4.755

Review 5.  Autophagy in gastrointestinal cancers.

Authors:  Bo-Zong Shao; Ning-Li Chai; Yi Yao; Jin-Ping Li; Helen Ka Wai Law; En-Qiang Linghu
Journal:  Front Oncol       Date:  2022-08-26       Impact factor: 5.738

6.  Identification of glycogene signature as a tool to predict the clinical outcome and immunotherapy response in breast cancer.

Authors:  Shuai Lin; Zengqi Tan; Hanxiao Cui; Qilong Ma; Xuyan Zhao; Jianhua Wu; Luyao Dai; Huafeng Kang; Feng Guan; Zhijun Dai
Journal:  Front Oncol       Date:  2022-09-14       Impact factor: 5.738
  6 in total

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