| Literature DB >> 33715965 |
Alexandros Laios1, Sara Duarte Portela2, Argyro Papadopoulou3, Ioannis D Gallos4, Mohamed Otify5, Thomas Ind6.
Abstract
Cervical cancer is the fourth most common female malignancy worldwide. As the focus of treatment is shifting towards balancing oncological outcomes with reproductive benefit, women are becoming increasingly aware of their fertility options. Cervical cancer is one of the primary malignancies where transposition of the ovaries may be indicated. Ovarian transposition should be performed in pre-menopausal women, undergoing pelvic irradiation to preserve ovarian function and prevent early menopause. The review discusses the available literature and synthesises a concise summary for gynaecologic oncology surgeons to counsel affected women. The paradoxical controversy, leading to its under use is acknowledged, due to the scarcity of published data with regard to functional outcomes, and the lack of clinical trials. In cervical cancer, ovarian transposition remains a safe fertility preservation (FP) option, which is associated with high ovarian function preservation, an acceptable rate of ovarian cysts and a negligible risk for metastases in the transposed ovaries.Entities:
Keywords: Cervical cancer; Fertility preservation; Ovarian function; Ovarian transposition; Pelvic radiotherapy
Year: 2021 PMID: 33715965 DOI: 10.1016/j.bpobgyn.2021.01.013
Source DB: PubMed Journal: Best Pract Res Clin Obstet Gynaecol ISSN: 1521-6934 Impact factor: 5.237