Literature DB >> 33715827

Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.

Chloe Lopez-Lee1, Lay Kodama2, Li Gan3.   

Abstract

Growing evidence supports significant involvement of immune dysfunction in the etiology of neurodegenerative diseases, several of which also display prominent sex differences across prevalence, pathology, and symptomology. In this review, we summarize evidence from human studies of established and recent findings of sex differences in multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis and discuss how sex-specific central nervous system innate immune activity could contribute to downstream sex differences in these diseases. We examine human genomic and transcriptomics studies in each neurodegenerative disease through the lens of sex differences in the neuroimmune system and highlight the importance of stratifying sex in clinical and translational research studies. Finally, we discuss the limitations of the existing studies and outline recommendations for further advancing sex-based analyses to uncover novel disease mechanisms that could ultimately help treat both sexes.
Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GWAS; Immune responses; Inflammation; Neurodegeneration; Sex difference; Transcriptomics

Mesh：

Year:  2021        PMID： 33715827      PMCID： PMC8263798          DOI： 10.1016/j.biopsych.2021.01.002

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  113 in total

1.  TREM2 and neurodegenerative disease.

Authors:  Thorlakur Jonsson; Kari Stefansson
Journal:  N Engl J Med       Date:  2013-10-17       Impact factor: 91.245

Review 2.  Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis.

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3.  Higher rates of decline for women and apolipoprotein E epsilon4 carriers.

Authors:  D Holland; R S Desikan; A M Dale; L K McEvoy
Journal:  AJNR Am J Neuroradiol       Date:  2013-07-04       Impact factor: 3.825

4.  Gender differences in Parkinson's disease.

Authors:  Charlotte A Haaxma; Bastiaan R Bloem; George F Borm; Wim J G Oyen; Klaus L Leenders; Silvia Eshuis; Jan Booij; Dean E Dluzen; Martin W I M Horstink
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-11-10       Impact factor: 10.154

5.  Sex modifies the APOE-related risk of developing Alzheimer disease.

Authors:  Andre Altmann; Lu Tian; Victor W Henderson; Michael D Greicius
Journal:  Ann Neurol       Date:  2014-04-14       Impact factor: 10.422

Review 6.  Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice.

Authors:  Jiann-Jyh Lai; Kuo-Pao Lai; Weiping Zeng; Kuang-Hsiang Chuang; Saleh Altuwaijri; Chawnshang Chang
Journal:  Am J Pathol       Date:  2012-09-04       Impact factor: 4.307

7.  Gender-related differences in MS: a study of conventional and nonconventional MRI measures.

Authors:  R Antulov; B Weinstock-Guttman; J L Cox; S Hussein; J Durfee; C Caiola; M G Dwyer; N Bergsland; N Abdelrahman; M Stosic; D Hojnacki; F E Munschauer; D Miletic; R Zivadinov
Journal:  Mult Scler       Date:  2008-11-21       Impact factor: 6.312

8.  Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Authors:  Yuetiva Deming; Logan Dumitrescu; Lisa L Barnes; Madhav Thambisetty; Brian Kunkle; Katherine A Gifford; William S Bush; Lori B Chibnik; Shubhabrata Mukherjee; Philip L De Jager; Walter Kukull; Matt Huentelman; Paul K Crane; Susan M Resnick; C Dirk Keene; Thomas J Montine; Gerard D Schellenberg; Jonathan L Haines; Henrik Zetterberg; Kaj Blennow; Eric B Larson; Sterling C Johnson; Marilyn Albert; Abhay Moghekar; Jorge L Del Aguila; Maria Victoria Fernandez; John Budde; Jason Hassenstab; Anne M Fagan; Matthias Riemenschneider; Ronald C Petersen; Lennart Minthon; Michael J Chao; Vivianna M Van Deerlin; Virginia M-Y Lee; Leslie M Shaw; John Q Trojanowski; Elaine R Peskind; Gail Li; Lea K Davis; Julia M Sealock; Nancy J Cox; Alison M Goate; David A Bennett; Julie A Schneider; Angela L Jefferson; Carlos Cruchaga; Timothy J Hohman
Journal:  Acta Neuropathol       Date:  2018-07-02       Impact factor: 17.088

9.  Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Authors:  Timothy R Hammond; Connor Dufort; Lasse Dissing-Olesen; Stefanie Giera; Adam Young; Alec Wysoker; Alec J Walker; Frederick Gergits; Michael Segel; James Nemesh; Samuel E Marsh; Arpiar Saunders; Evan Macosko; Florent Ginhoux; Jinmiao Chen; Robin J M Franklin; Xianhua Piao; Steven A McCarroll; Beth Stevens
Journal:  Immunity       Date:  2018-11-21       Impact factor: 31.745

10.  A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis.

Authors:  Johnathan Cooper-Knock; Claire Green; Gabriel Altschuler; Wenbin Wei; Joanna J Bury; Paul R Heath; Matthew Wyles; Catherine Gelsthorpe; J Robin Highley; Alejandro Lorente-Pons; Tim Beck; Kathryn Doyle; Karel Otero; Bryan Traynor; Janine Kirby; Pamela J Shaw; Winston Hide
Journal:  Acta Neuropathol Commun       Date:  2017-03-16       Impact factor: 7.801
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  9 in total

1.  Sex Differences in Innate Immune Response of Peripheral Blood Leukocytes of Alzheimer's Disease Patients.

Authors:  Marta Sochocka; Michał Ochnik; Maciej Sobczyński; Beata Orzechowska; Jerzy Leszek
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2022-06-16       Impact factor: 4.291

2.  Introduction to Special Issue: Insight Into Sex Differences in Neuropsychiatric Syndromes From Transcriptomic Analyses.

Authors:  Marianne L Seney; Eric J Nestler
Journal:  Biol Psychiatry       Date:  2022-01-01       Impact factor: 13.382

3.  Network Analysis Identifies Sex-Specific Gene Expression Changes in Blood of Amyotrophic Lateral Sclerosis Patients.

Authors:  Jose A Santiago; James P Quinn; Judith A Potashkin
Journal:  Int J Mol Sci       Date:  2021-07-01       Impact factor: 5.923

4.  Tackling the Biological Meaning of the Human Olfactory Bulb Dyshomeostatic Proteome across Neurological Disorders: An Integrative Bioinformatic Approach.

Authors:  Paz Cartas-Cejudo; Mercedes Lachén-Montes; Joaquín Fernández-Irigoyen; Enrique Santamaría
Journal:  Int J Mol Sci       Date:  2021-10-20       Impact factor: 5.923

Review 5.  Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease.

Authors:  Steven N Austad; Scott Ballinger; Thomas W Buford; Christy S Carter; Daniel L Smith; Victor Darley-Usmar; Jianhua Zhang
Journal:  Acta Pharm Sin B       Date:  2021-06-30       Impact factor: 11.413

6.  Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.

Authors:  Jaclyn M Eissman; Logan Dumitrescu; Emily R Mahoney; Alexandra N Smith; Shubhabrata Mukherjee; Michael L Lee; Phoebe Scollard; Seo Eun Choi; William S Bush; Corinne D Engelman; Qiongshi Lu; David W Fardo; Emily H Trittschuh; Jesse Mez; Catherine C Kaczorowski; Hector Hernandez Saucedo; Keith F Widaman; Rachel F Buckley; Michael J Properzi; Elizabeth C Mormino; Hyun Sik Yang; Theresa M Harrison; Trey Hedden; Kwangsik Nho; Shea J Andrews; Douglas Tommet; Niran Hadad; R Elizabeth Sanders; Douglas M Ruderfer; Katherine A Gifford; Xiaoyuan Zhong; Neha S Raghavan; Badri N Vardarajan; Margaret A Pericak-Vance; Lindsay A Farrer; Li San Wang; Carlos Cruchaga; Gerard D Schellenberg; Nancy J Cox; Jonathan L Haines; C Dirk Keene; Andrew J Saykin; Eric B Larson; Reisa A Sperling; Richard Mayeux; Michael L Cuccaro; David A Bennett; Julie A Schneider; Paul K Crane; Angela L Jefferson; Timothy J Hohman
Journal:  Brain       Date:  2022-07-29       Impact factor: 15.255

7.  Immune-mediated diseases are associated with a higher incidence of dementia: a prospective cohort study of 375,894 individuals.

Authors:  Ya-Ru Zhang; Liu Yang; Hui-Fu Wang; Bang-Sheng Wu; Shu-Yi Huang; Wei Cheng; Jian-Feng Feng; Jin-Tai Yu
Journal:  Alzheimers Res Ther       Date:  2022-09-13       Impact factor: 8.823

8.  Angiotensin II differentially affects hippocampal glial inflammatory markers in young adult male and female mice.

Authors:  Teresa A Milner; Ryan X Chen; Diedreanna Welington; Batsheva R Rubin; Natalina H Contoreggi; Megan A Johnson; Sanoara Mazid; Jose Marques-Lopes; Roberta Marongiu; Michael J Glass
Journal:  Learn Mem       Date:  2022-09-06       Impact factor: 2.699

Review 9.  Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age.

Authors:  Ashley Payne; Samuel Nahashon; Equar Taka; Getinet M Adinew; Karam F A Soliman
Journal:  Biomolecules       Date:  2022-02-25
  9 in total

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