Xiaomin Wu1, Zengmiao Wang2, Zhenyu He3, Yapin Li4, Huaiyu Tian5, Yating Wu1, Huaiji Wang1, Yonghong Liu5, Fanghua Hao6. 1. Wuhan Center for Disease Control and Prevention, Wuhan, China. 2. State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China. wangzengmiao@gmail.com. 3. Wuhan Center for Disease Control and Prevention, Wuhan, China. hosan9174@163.com. 4. Central Theater Center for Disease Control and Prevention of PLA, Beijing, China. 5. State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China. 6. Central China Normal University, Wuhan, China.
Abstract
BACKGROUND: Previous studies showed that recovered coronavirus disease 2019 (COVID-19) patients can have a subsequent positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after they are discharged from the hospital. Understanding the epidemiological characteristics of recovered COVID-19 patients who have a re-positive test is vital for preventing a second wave of COVID-19. METHODS: This retrospective study analyzed the epidemiological and clinical features of 20,280 COVID-19 patients from multiple centers in Wuhan who had a positive PCR test between December 31, 2019, and August 4, 2020. The RT-PCR test results for 4079 individuals who had close contact with the re-positive cases were also obtained. RESULTS: In total, 2466 (12.16%) of the 20,280 patients had a re-positive SARS-CoV-2 PCR test after they were discharged from the hospital, and 4079 individuals had close contact with members of this patient group. All of these 4079 individuals had a negative SARS-CoV-2 PCR test. CONCLUSIONS: This retrospective study in Wuhan analyzed the basic characteristics of recovered COVID-19 patients with re-positive PCR test and found that these cases may not be infectious.
BACKGROUND: Previous studies showed that recovered coronavirus disease 2019 (COVID-19) patients can have a subsequent positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after they are discharged from the hospital. Understanding the epidemiological characteristics of recovered COVID-19patients who have a re-positive test is vital for preventing a second wave of COVID-19. METHODS: This retrospective study analyzed the epidemiological and clinical features of 20,280 COVID-19patients from multiple centers in Wuhan who had a positive PCR test between December 31, 2019, and August 4, 2020. The RT-PCR test results for 4079 individuals who had close contact with the re-positive cases were also obtained. RESULTS: In total, 2466 (12.16%) of the 20,280 patients had a re-positive SARS-CoV-2 PCR test after they were discharged from the hospital, and 4079 individuals had close contact with members of this patient group. All of these 4079 individuals had a negative SARS-CoV-2 PCR test. CONCLUSIONS: This retrospective study in Wuhan analyzed the basic characteristics of recovered COVID-19patients with re-positive PCR test and found that these cases may not be infectious.
Entities:
Keywords:
COVID-19; Close contact; Repeat positive; Subsequent infection
Authors: Tawanda Chivese; Joshua T Matizanadzo; Omran A H Musa; George Hindy; Luis Furuya-Kanamori; Nazmul Islam; Rafal Al-Shebly; Rana Shalaby; Mohammad Habibullah; Talal A Al-Marwani; Rizeq F Hourani; Ahmed D Nawaz; Mohammad Z Haider; Mohamed M Emara; Farhan Cyprian; Suhail A R Doi Journal: Pathog Glob Health Date: 2022-01-31 Impact factor: 3.735
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